Gene Name	HGNC ID	COSMIC_MutID	Primary site	Primary histology	AA-Mutation	Mutation Type	Genomic Position	FATHMM prediction	FATHMM score	Literature evidence
BRCA1	1100	COSM6937357,	lung	carcinoma	p.Q780E	Substitution - Missense	17:43093193-43093193,	PATHOGENIC	0.99155	28481359
BRCA1	1100	COSM6965065,	soft_tissue	angiosarcoma	p.S1292A	Substitution - Missense	17:43091657-43091657,	PATHOGENIC	0.98619	28481359
BRCA1	1100	COSM6952377,	large_intestine	carcinoma	p.S1292Y	Substitution - Missense	17:43091656-43091656,	PATHOGENIC	0.98018	28481359
BRCA1	1100	COSM6924781,	breast	carcinoma	p.Q1395E	Substitution - Missense	17:43090946-43090946,	PATHOGENIC	0.97878	28481359
BRCA1	1100	COSM6914629,	lung	carcinoma	p.E648Q	Substitution - Missense	17:43093589-43093589,	PATHOGENIC	0.9775	28481359
BRCA1	1100	COSM6923548,	urinary_tract	carcinoma	p.S1292F	Substitution - Missense	17:43091656-43091656,	PATHOGENIC	0.97675	28481359
BRCA1	1100	COSM6931524,	breast	carcinoma	p.E648*	Substitution - Nonsense	17:43093589-43093589,	PATHOGENIC	0.97631	28481359
BRCA1	1100	COSM6927029,	large_intestine	carcinoma	p.T77M	Substitution - Missense	17:43104939-43104939,	PATHOGENIC	0.97585	28481359
BRCA1	1100	COSM6947416,	soft_tissue	malignant_peripheral_nerve_sheath_tumour	p.E1419G	Substitution - Missense	17:43082505-43082505,	PATHOGENIC	0.97494	28481359
BRCA1	1100	COSM6983533,	skin	malignant_melanoma	p.P62L	Substitution - Missense	17:43106483-43106483,	PATHOGENIC	0.97408	28481359
BRCA1	1100	COSM6971902,	endometrium	carcinoma	p.V1713A	Substitution - Missense	17:43063888-43063888,	PATHOGENIC	0.97372	28481359
BRCA1	1100	COSM6981753,	pancreas	carcinoma	p.Q1388*	Substitution - Nonsense	17:43090967-43090967,	PATHOGENIC	0.97357	28481359
BRCA1	1100	COSM35895,	breast	carcinoma	p.?	Unknown	17:43057051-43057051,	PATHOGENIC	0.97246	19593635
BRCA1	1100	COSM6910109,	soft_tissue	leiomyosarcoma	p.L1365F	Substitution - Missense	17:43091436-43091436,	PATHOGENIC	0.97227	28481359
BRCA1	1100	COSM5575478,	ovary	carcinoma	p.E384V	Substitution - Missense	17:43094380-43094380,	PATHOGENIC	0.97156	25846551
BRCA1	1100	COSM5575478,	ovary	carcinoma	p.E384V	Substitution - Missense	17:43094380-43094380,	PATHOGENIC	0.97156	25846551
BRCA1	1100	COSM6943403,	urinary_tract	carcinoma	p.E648K	Substitution - Missense	17:43093589-43093589,	PATHOGENIC	0.97155	28481359
BRCA1	1100	COSM6969903,	lung	carcinoma	p.E848*	Substitution - Nonsense	17:43092989-43092989,	PATHOGENIC	0.969	28481359
BRCA1	1100	COSM6976891,	central_nervous_system	glioma	p.E1214K	Substitution - Missense	17:43091891-43091891,	PATHOGENIC	0.96861	28481359
BRCA1	1100	COSM6922027,	endometrium	carcinoma	p.?	Unknown	17:43104957-43104957,	PATHOGENIC	0.96851	28481359
BRCA1	1100	COSM6922027,	prostate	carcinoma	p.?	Unknown	17:43104957-43104957,	PATHOGENIC	0.96851	28481359
BRCA1	1100	COSM6931077,	urinary_tract	carcinoma	p.E649Q	Substitution - Missense	17:43093586-43093586,	PATHOGENIC	0.96851	28481359
BRCA1	1100	COSM6940248,	breast	carcinoma	p.Q81E	Substitution - Missense	17:43104928-43104928,	PATHOGENIC	0.96668	28481359
BRCA1	1100	COSM6955977,	lung	carcinoma	p.A1708E	Substitution - Missense	17:43063903-43063903,	PATHOGENIC	0.96498	28481359
BRCA1	1100	COSM5414819,	lung	carcinoma	p.R71K	Substitution - Missense	17:43106456-43106456,	PATHOGENIC	0.96417	29420467
BRCA1	1100	COSM5575278,	ovary	carcinoma	p.S198N	Substitution - Missense	17:43097244-43097244,	PATHOGENIC	0.96214	25846551
BRCA1	1100	COSM5575278,	ovary	carcinoma	p.S198N	Substitution - Missense	17:43097244-43097244,	PATHOGENIC	0.96214	25846551
BRCA1	1100	COSM5575278,	ovary	carcinoma	p.S198N	Substitution - Missense	17:43097244-43097244,	PATHOGENIC	0.96214	25846551
BRCA1	1100	COSM5575278,	ovary	carcinoma	p.S198N	Substitution - Missense	17:43097244-43097244,	PATHOGENIC	0.96214	25846551
BRCA1	1100	COSM5575278,	ovary	carcinoma	p.S198N	Substitution - Missense	17:43097244-43097244,	PATHOGENIC	0.96214	25846551
BRCA1	1100	COSM5575278,	ovary	carcinoma	p.S198N	Substitution - Missense	17:43097244-43097244,	PATHOGENIC	0.96214	25846551
BRCA1	1100	COSM5575278,	ovary	carcinoma	p.S198N	Substitution - Missense	17:43097244-43097244,	PATHOGENIC	0.96214	25846551
BRCA1	1100	COSM5575278,	ovary	carcinoma	p.S198N	Substitution - Missense	17:43097244-43097244,	PATHOGENIC	0.96214	25846551
BRCA1	1100	COSM6948017,	large_intestine	carcinoma	p.V1653A	Substitution - Missense	17:43070956-43070956,	PATHOGENIC	0.95704	28481359
BRCA1	1100	COSM6916176,	ovary	carcinoma	p.A1708P	Substitution - Missense	17:43063904-43063904,	PATHOGENIC	0.95329	28481359
BRCA1	1100	COSM6918021,	upper_aerodigestive_tract	carcinoma	p.Q380E	Substitution - Missense	17:43094393-43094393,	PATHOGENIC	0.95087	28481359
BRCA1	1100	COSM5607948,	skin	malignant_melanoma	p.W1718L	Substitution - Missense	17:43063373-43063373,	PATHOGENIC	0.94897	26343386
BRCA1	1100	COSM6940664,	skin	malignant_melanoma	p.G1743V	Substitution - Missense	17:43057101-43057101,	PATHOGENIC	0.94769	28481359
BRCA1	1100	COSM5575521,	large_intestine	carcinoma	p.K1208T	Substitution - Missense	17:43091908-43091908,	PATHOGENIC	0.94583	28481359
BRCA1	1100	COSM5575521,	ovary	carcinoma	p.K1208T	Substitution - Missense	17:43091908-43091908,	PATHOGENIC	0.94583	25846551
BRCA1	1100	COSM6956683,	soft_tissue	fibrosarcoma	p.H1686Y	Substitution - Missense	17:43067626-43067626,	PATHOGENIC	0.94419	28481359
BRCA1	1100	COSM6942615,	oesophagus	carcinoma	p.A1708T	Substitution - Missense	17:43063904-43063904,	PATHOGENIC	0.9395	28481359
BRCA1	1100	COSM6976505,	large_intestine	carcinoma	p.?	Unknown	17:43067696-43067696,	PATHOGENIC	0.93816	28481359
BRCA1	1100	COSM5575301,	ovary	carcinoma	p.K50R	Substitution - Missense	17:43106519-43106519,	PATHOGENIC	0.9377	25846551
BRCA1	1100	COSM4991001,	skin	carcinoma	p.P1192L	Substitution - Missense	17:43091956-43091956,	PATHOGENIC	0.93523	25589618
BRCA1	1100	COSM7325203,	biliary_tract	carcinoma	p.?	Unknown	17:43104262-43104262,	PATHOGENIC	0.93473	29360550
BRCA1	1100	COSM6933874,	lung	carcinoma	p.R1751L	Substitution - Missense	17:43057077-43057077,	PATHOGENIC	0.9279	28481359
BRCA1	1100	COSM6940192,	lung	carcinoma	p.Q1388H	Substitution - Missense	17:43090965-43090965,	PATHOGENIC	0.92754	28481359
BRCA1	1100	COSM6922162,	lung	carcinoma	p.S267L	Substitution - Missense	17:43094731-43094731,	PATHOGENIC	0.9253	28481359
BRCA1	1100	COSM6907122,	urinary_tract	carcinoma	p.S1387F	Substitution - Missense	17:43090969-43090969,	PATHOGENIC	0.92294	29420467
BRCA1	1100	COSM6957807,	large_intestine	carcinoma	p.P115R	Substitution - Missense	17:43104219-43104219,	PATHOGENIC	0.92236	28481359
BRCA1	1100	COSM6923811,	lung	carcinoma	p.D642H	Substitution - Missense	17:43093607-43093607,	PATHOGENIC	0.92177	28481359
BRCA1	1100	COSM6928132,	urinary_tract	carcinoma	p.S426L	Substitution - Missense	17:43094254-43094254,	PATHOGENIC	0.91859	28481359
BRCA1	1100	COSM6965063,	soft_tissue	angiosarcoma	p.E1358K	Substitution - Missense	17:43091459-43091459,	PATHOGENIC	0.91757	28481359
BRCA1	1100	COSM5575488,	ovary	carcinoma	p.T775N	Substitution - Missense	17:43093207-43093207,	PATHOGENIC	0.91457	25846551
BRCA1	1100	COSM6973588,	skin	malignant_melanoma	p.Q1408*	Substitution - Nonsense	17:43082539-43082539,	PATHOGENIC	0.91261	28481359
BRCA1	1100	COSM6928112,	urinary_tract	carcinoma	p.E1836K	Substitution - Missense	17:43045764-43045764,	PATHOGENIC	0.91246	28481359
BRCA1	1100	COSM6969336,	oesophagus	carcinoma	p.P115L	Substitution - Missense	17:43104219-43104219,	PATHOGENIC	0.91236	28481359
BRCA1	1100	COSM6923800,	cervix	carcinoma	p.D120A	Substitution - Missense	17:43104204-43104204,	PATHOGENIC	0.90884	28481359
BRCA1	1100	COSM24520,	ovary	carcinoma	p.?	Unknown	17:43051118-43051118,	PATHOGENIC	0.90693	11240689
BRCA1	1100	COSM6984612,	endometrium	carcinoma	p.D1152N	Substitution - Missense	17:43092077-43092077,	PATHOGENIC	0.90603	28481359
BRCA1	1100	COSM6962657,	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	p.?	Unknown	17:43071239-43071239,	PATHOGENIC	0.90526	28481359
BRCA1	1100	COSM6944673,	soft_tissue	malignant_fibrous_histiocytoma-pleomorphic_sarcoma	p.?	Unknown	17:43099773-43099773,	PATHOGENIC	0.90469	28481359
BRCA1	1100	COSM6995429,	ovary	germ_cell_tumour	p.L52V	Substitution - Missense	17:43106514-43106514,	PATHOGENIC	0.90353	28954785
BRCA1	1100	COSM6995429,	ovary	germ_cell_tumour	p.L52V	Substitution - Missense	17:43106514-43106514,	PATHOGENIC	0.90353	28954785
BRCA1	1100	COSM5020686,	soft_tissue	haemangioblastoma	p.Y179H	Substitution - Missense	17:43099787-43099787,	PATHOGENIC	0.90279	25589003
BRCA1	1100	COSM5464046,	thyroid	carcinoma	p.R1751Q	Substitution - Missense	17:43057077-43057077,	PATHOGENIC	0.90094	28481359
BRCA1	1100	COSM3755569,	soft_tissue	haemangioblastoma	p.Q356R	Substitution - Missense	17:43094464-43094464,	PATHOGENIC	0.89866	25589003
BRCA1	1100	COSM3755569,	breast	carcinoma	p.Q356R	Substitution - Missense	17:43094464-43094464,	PATHOGENIC	0.89866	24185512
BRCA1	1100	COSM3755569,	breast	carcinoma	p.Q356R	Substitution - Missense	17:43094464-43094464,	PATHOGENIC	0.89866	24185512
BRCA1	1100	COSM3755569,	soft_tissue	haemangioblastoma	p.Q356R	Substitution - Missense	17:43094464-43094464,	PATHOGENIC	0.89866	25589003
BRCA1	1100	COSM6936779,	prostate	carcinoma	p.D40N	Substitution - Missense	17:43115742-43115742,	PATHOGENIC	0.89461	28481359
BRCA1	1100	COSM6913507,	skin	carcinoma	p.L182S	Substitution - Missense	17:43099777-43099777,	PATHOGENIC	0.8938	28481359
BRCA1	1100	COSM6948729,	skin	malignant_melanoma	p.P1562L	Substitution - Missense	17:43071229-43071229,	PATHOGENIC	0.89079	28481359
BRCA1	1100	COSM5607958,	skin	malignant_melanoma	p.P871S	Substitution - Missense	17:43092920-43092920,	PATHOGENIC	0.89052	26343386
BRCA1	1100	COSM24528,	ovary	carcinoma	p.E1725*	Substitution - Nonsense	17:43063353-43063353,	PATHOGENIC	0.8901	7795652
BRCA1	1100	COSM6918841,	thyroid	carcinoma	p.L1705V	Substitution - Missense	17:43063913-43063913,	PATHOGENIC	0.88706	28481359
BRCA1	1100	COSM6965969,	skin	malignant_melanoma	p.E1725K	Substitution - Missense	17:43063353-43063353,	PATHOGENIC	0.88203	28481359
BRCA1	1100	COSM6981150,	lung	carcinoma	p.N1742I	Substitution - Missense	17:43057104-43057104,	PATHOGENIC	0.87726	28481359
BRCA1	1100	COSM6932042,	central_nervous_system	glioma	p.V1654M	Substitution - Missense	17:43070954-43070954,	PATHOGENIC	0.87708	28481359
BRCA1	1100	COSM7325210,	biliary_tract	carcinoma	p.Q563K	Substitution - Missense	17:43093844-43093844,	PATHOGENIC	0.87232	29360550
BRCA1	1100	COSM6984164,	urinary_tract	carcinoma	p.Q544*	Substitution - Nonsense	17:43093901-43093901,	PATHOGENIC	0.87201	28481359
BRCA1	1100	COSM6986492,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.Y179C	Substitution - Missense	17:43099786-43099786,	PATHOGENIC	0.86183	28481359
BRCA1	1100	COSM6924394,	urinary_tract	carcinoma	p.E1754Q	Substitution - Missense	17:43057069-43057069,	PATHOGENIC	0.85311	28481359
BRCA1	1100	COSM6954055,	skin	malignant_melanoma	p.E1754K	Substitution - Missense	17:43057069-43057069,	PATHOGENIC	0.85201	28481359
BRCA1	1100	COSM6940458,	urinary_tract	carcinoma	p.E1060D	Substitution - Missense	17:43092351-43092351,	PATHOGENIC	0.85033	28481359
BRCA1	1100	COSM6950033,	NS	carcinoma	p.G1567*	Substitution - Nonsense	17:43071215-43071215,	PATHOGENIC	0.84888	28481359
BRCA1	1100	COSM5575372,	ovary	carcinoma	p.D1343E	Substitution - Missense	17:43091502-43091502,	PATHOGENIC	0.84373	25846551
BRCA1	1100	COSM6930929,	ovary	carcinoma	p.E1167*	Substitution - Nonsense	17:43092032-43092032,	PATHOGENIC	0.83007	28481359
BRCA1	1100	COSM6936547,	urinary_tract	carcinoma	p.E1817K	Substitution - Missense	17:43047661-43047661,	PATHOGENIC	0.82962	28481359
BRCA1	1100	COSM6934977,	upper_aerodigestive_tract	carcinoma	p.C24F	Substitution - Missense	17:43124026-43124026,	PATHOGENIC	0.82648	28481359
BRCA1	1100	COSM3734724,	ovary	carcinoma	p.?	Unknown	17:43124016-43124016,	PATHOGENIC	0.82613	9796975
BRCA1	1100	COSM93980,	lung	carcinoma	p.M297V	Substitution - Missense	17:43094642-43094642,	PATHOGENIC	0.82368	20668451
BRCA1	1100	COSM6918178,	lung	carcinoma	p.E1053K	Substitution - Missense	17:43092374-43092374,	PATHOGENIC	0.81523	28481359
BRCA1	1100	COSM6934372,	lung	carcinoma	p.L512F	Substitution - Missense	17:43093997-43093997,	PATHOGENIC	0.81139	28481359
BRCA1	1100	COSM6934372,	oesophagus	carcinoma	p.L512F	Substitution - Missense	17:43093997-43093997,	PATHOGENIC	0.81139	28481359
BRCA1	1100	COSM4991003,	skin	carcinoma	p.P1192S	Substitution - Missense	17:43091957-43091957,	PATHOGENIC	0.81102	25589618
BRCA1	1100	COSM4985686,	soft_tissue	haemangioblastoma	p.M1652I	Substitution - Missense	17:43070958-43070958,	PATHOGENIC	0.80959	25589003
BRCA1	1100	COSM6929869,	lung	carcinoma	p.L283V	Substitution - Missense	17:43094684-43094684,	PATHOGENIC	0.80633	28481359
BRCA1	1100	COSM5575464,	ovary	carcinoma	p.H41Q	Substitution - Missense	17:43115737-43115737,	PATHOGENIC	0.8053	25846551
BRCA1	1100	COSM5020112,	soft_tissue	haemangioblastoma	p.C197C	Substitution - coding silent	17:43097246-43097246,	PATHOGENIC	0.80468	25589003
BRCA1	1100	COSM6935538,	endometrium	carcinoma	p.S265Y	Substitution - Missense	17:43094737-43094737,	PATHOGENIC	0.80409	28481359
BRCA1	1100	COSM1577248,	ovary	carcinoma	p.E1794*	Substitution - Nonsense	17:43049147-43049147,	PATHOGENIC	0.80016	23633455
BRCA1	1100	COSM6927705,	breast	carcinoma	p.I373L	Substitution - Missense	17:43094414-43094414,	PATHOGENIC	0.79956	28481359
BRCA1	1100	COSM5025050,	breast	carcinoma	p.L30F	Substitution - Missense	17:43115770-43115770,	PATHOGENIC	0.79226	25850943
BRCA1	1100	COSM6908861,	stomach	carcinoma	p.K1793N	Substitution - Missense	17:43049148-43049148,	PATHOGENIC	0.79166	28481359
BRCA1	1100	COSM6962603,	skin	carcinoma	p.Q317*	Substitution - Nonsense	17:43094582-43094582,	PATHOGENIC	0.78613	28481359
BRCA1	1100	COSM23958,	breast	carcinoma	p.W372*	Substitution - Nonsense	17:43094415-43094415,	PATHOGENIC	0.78292	15712267
BRCA1	1100	COSM23933,	ovary	carcinoma	p.S1009*	Substitution - Nonsense	17:43092505-43092505,	PATHOGENIC	0.78281	10467410
BRCA1	1100	COSM13841,	breast	carcinoma	p.L30F	Substitution - Missense	17:43115770-43115770,	PATHOGENIC	0.77986	16959974
BRCA1	1100	COSM5575468,	ovary	carcinoma	p.L147M	Substitution - Missense	17:43104124-43104124,	PATHOGENIC	0.77925	25846551
BRCA1	1100	COSM5575267,	ovary	carcinoma	p.A1823S	Substitution - Missense	17:43047643-43047643,	PATHOGENIC	0.76815	25846551
BRCA1	1100	COSM6974518,	breast	carcinoma	p.K1724*	Substitution - Nonsense	17:43063356-43063356,	PATHOGENIC	0.76598	28481359
BRCA1	1100	COSM6506421,	breast	carcinoma	p.E1419*	Substitution - Nonsense	17:43082506-43082506,	PATHOGENIC	0.75857	26011570
BRCA1	1100	COSM6956872,	oesophagus	carcinoma	p.E1683D	Substitution - Missense	17:43067633-43067633,	PATHOGENIC	0.75746	28481359
BRCA1	1100	COSM6956872,	stomach	carcinoma	p.E1683D	Substitution - Missense	17:43067633-43067633,	PATHOGENIC	0.75746	28481359
BRCA1	1100	COSM6923475,	lung	carcinoma	p.Q1356E	Substitution - Missense	17:43091465-43091465,	PATHOGENIC	0.75042	28481359
BRCA1	1100	COSM6995494,	ovary	germ_cell_tumour	p.L1844L	Substitution - coding silent	17:43045738-43045738,	PATHOGENIC	0.74374	28954785
BRCA1	1100	COSM6937197,	skin	carcinoma	p.A224S	Substitution - Missense	17:43095846-43095846,	PATHOGENIC	0.74188	28481359
BRCA1	1100	COSM6933613,	urinary_tract	carcinoma	p.R1726T	Substitution - Missense	17:43063349-43063349,	PATHOGENIC	0.73959	28481359
BRCA1	1100	COSM6980843,	endometrium	carcinoma	p.Q1848R	Substitution - Missense	17:43045727-43045727,	PATHOGENIC	0.73275	28481359
BRCA1	1100	COSM6978590,	breast	carcinoma	p.Y101N	Substitution - Missense	17:43104868-43104868,	PATHOGENIC	0.7194	28481359
BRCA1	1100	COSM48262,	lung	carcinoma	p.G1077W	Substitution - Missense	17:43092302-43092302,	PATHOGENIC	0.70213	18948947
BRCA1	1100	COSM6949403,	breast	carcinoma	p.E1066K	Substitution - Missense	17:43092335-43092335,	PATHOGENIC	0.70157	28481359
BRCA1	1100	COSM5575370,	ovary	carcinoma	p.?	Unknown	17:43074525-43074525,	NEUTRAL	0.48555	25846551
BRCA1	1100	COSM6936279,	lung	carcinoma	p.S889C	Substitution - Missense	17:43092865-43092865,	NEUTRAL	0.48468	28481359
BRCA1	1100	COSM6923992,	central_nervous_system	glioma	p.D430N	Substitution - Missense	17:43094243-43094243,	NEUTRAL	0.47513	28481359
BRCA1	1100	COSM6958307,	skin	malignant_melanoma	p.E1373K	Substitution - Missense	17:43091012-43091012,	NEUTRAL	0.46226	28481359
BRCA1	1100	COSM6921165,	skin	malignant_melanoma	p.D1757E	Substitution - Missense	17:43057058-43057058,	NEUTRAL	0.41153	28481359
BRCA1	1100	COSM6960734,	skin	malignant_melanoma	p.E638D	Substitution - Missense	17:43093617-43093617,	NEUTRAL	0.4038	28481359
BRCA1	1100	COSM3190097,	oesophagus	carcinoma	p.K604E	Substitution - Missense	17:43093721-43093721,	NEUTRAL	0.39925	24686850
BRCA1	1100	COSM6906937,	urinary_tract	carcinoma	p.S1551C	Substitution - Missense	17:43074354-43074354,	NEUTRAL	0.38037	28481359
BRCA1	1100	COSM6906937,	urinary_tract	carcinoma	p.S1551C	Substitution - Missense	17:43074354-43074354,	NEUTRAL	0.38037	29420467
BRCA1	1100	COSM6906937,	lung	carcinoma	p.S1551C	Substitution - Missense	17:43074354-43074354,	NEUTRAL	0.38037	28481359
BRCA1	1100	COSM6950330,	NS	carcinoma	p.D1813N	Substitution - Missense	17:43047673-43047673,	NEUTRAL	0.37931	28481359
BRCA1	1100	COSM5009696,	large_intestine	carcinoma	p.E1092V	Substitution - Missense	17:43092256-43092256,	NEUTRAL	0.33442	24951259
BRCA1	1100	COSM95782,	breast	carcinoma	p.L1335L	Substitution - coding silent	17:43091526-43091526,	NEUTRAL	0.33111	20668451
BRCA1	1100	COSM6911599,	large_intestine	carcinoma	p.T710I	Substitution - Missense	17:43093402-43093402,	NEUTRAL	0.32395	28481359
BRCA1	1100	COSM6911599,	large_intestine	carcinoma	p.T710I	Substitution - Missense	17:43093402-43093402,	NEUTRAL	0.32395	28481359
BRCA1	1100	COSM6919337,	large_intestine	carcinoma	p.K520N	Substitution - Missense	17:43093971-43093971,	NEUTRAL	0.32139	28481359
BRCA1	1100	COSM6951927,	salivary_gland	carcinoma	p.T1720I	Substitution - Missense	17:43063367-43063367,	NEUTRAL	0.32096	28481359
BRCA1	1100	COSM6950246,	central_nervous_system	glioma	p.E111K	Substitution - Missense	17:43104232-43104232,	NEUTRAL	0.30968	28481359
BRCA1	1100	COSM5575376,	ovary	carcinoma	p.N916I	Substitution - Missense	17:43092784-43092784,	NEUTRAL	0.30792	25846551
BRCA1	1100	COSM6937983,	urinary_tract	carcinoma	p.N113K	Substitution - Missense	17:43104224-43104224,	NEUTRAL	0.30662	28481359
BRCA1	1100	COSM5031244,	urinary_tract	carcinoma	p.E597K	Substitution - Missense	17:43093742-43093742,	NEUTRAL	0.30546	28481359
BRCA1	1100	COSM5031244,	urinary_tract	carcinoma	p.E597K	Substitution - Missense	17:43093742-43093742,	NEUTRAL	0.30546	28481359
BRCA1	1100	COSM93978,	lung	carcinoma	p.Q687P	Substitution - Missense	17:43093471-43093471,	NEUTRAL	0.30155	20668451
BRCA1	1100	COSM5731630,	NS	malignant_melanoma	p.N630H	Substitution - Missense	17:43093643-43093643,	NEUTRAL	0.29674	25886620
BRCA1	1100	COSM133663,	breast	carcinoma	p.S988*	Substitution - Nonsense	17:43092568-43092568,	NEUTRAL	0.29302	22116506
BRCA1	1100	COSM6964074,	lung	carcinoma	p.P1659L	Substitution - Missense	17:43070938-43070938,	NEUTRAL	0.29206	28481359
BRCA1	1100	COSM6933055,	urinary_tract	carcinoma	p.S1320C	Substitution - Missense	17:43091572-43091572,	NEUTRAL	0.2791	28481359
BRCA1	1100	COSM5575338,	ovary	carcinoma	p.N113S	Substitution - Missense	17:43104225-43104225,	NEUTRAL	0.27554	25846551
BRCA1	1100	COSM5575434,	salivary_gland	carcinoma	p.E842*	Substitution - Nonsense	17:43093007-43093007,	NEUTRAL	0.2739	27334835
BRCA1	1100	COSM5575434,	ovary	carcinoma	p.E842*	Substitution - Nonsense	17:43093007-43093007,	NEUTRAL	0.2739	25846551
BRCA1	1100	COSM5020169,	soft_tissue	haemangioblastoma	p.K1109N	Substitution - Missense	17:43092204-43092204,	NEUTRAL	0.2694	25589003
BRCA1	1100	COSM6959703,	lung	carcinoma	p.T1310S	Substitution - Missense	17:43091603-43091603,	NEUTRAL	0.26023	28481359
BRCA1	1100	COSM6943401,	urinary_tract	carcinoma	p.E649D	Substitution - Missense	17:43093584-43093584,	NEUTRAL	0.26023	28481359
BRCA1	1100	COSM6969846,	lung	carcinoma	p.E362G	Substitution - Missense	17:43094446-43094446,	NEUTRAL	0.2586	28481359
BRCA1	1100	COSM979730,	salivary_gland	carcinoma	p.R1443*	Substitution - Nonsense	17:43082434-43082434,	NEUTRAL	0.24687	27334835
BRCA1	1100	COSM6941397,	large_intestine	carcinoma	p.A1615V	Substitution - Missense	17:43071070-43071070,	NEUTRAL	0.24276	28481359
BRCA1	1100	COSM6947316,	lung	carcinoma	p.E904*	Substitution - Nonsense	17:43092821-43092821,	NEUTRAL	0.23506	28481359
BRCA1	1100	COSM7325182,	biliary_tract	carcinoma	p.E1107*	Substitution - Nonsense	17:43092212-43092212,	NEUTRAL	0.22756	29360550
BRCA1	1100	COSM6948420,	lung	carcinoma	p.S741F	Substitution - Missense	17:43093309-43093309,	NEUTRAL	0.22111	28481359
BRCA1	1100	COSM6942636,	large_intestine	carcinoma	p.K1264N	Substitution - Missense	17:43091739-43091739,	NEUTRAL	0.21609	28481359
BRCA1	1100	COSM6944157,	breast	carcinoma	p.P364R	Substitution - Missense	17:43094440-43094440,	NEUTRAL	0.2118	28481359
BRCA1	1100	COSM6907423,	urinary_tract	carcinoma	p.S1286T	Substitution - Missense	17:43091674-43091674,	NEUTRAL	0.20144	25225064
BRCA1	1100	COSM5575523,	ovary	carcinoma	p.N913Y	Substitution - Missense	17:43092794-43092794,	NEUTRAL	0.19983	25846551
BRCA1	1100	COSM6919916,	ovary	carcinoma	p.E1446*	Substitution - Nonsense	17:43082425-43082425,	NEUTRAL	0.19901	28481359
BRCA1	1100	COSM6956228,	large_intestine	carcinoma	p.L1564P	Substitution - Missense	17:43071223-43071223,	NEUTRAL	0.1972	28481359
BRCA1	1100	COSM6995466,	ovary	germ_cell_tumour	p.E349K	Substitution - Missense	17:43094486-43094486,	NEUTRAL	0.19181	28954785
BRCA1	1100	COSM6953777,	skin	carcinoma	p.P1190L	Substitution - Missense	17:43091962-43091962,	NEUTRAL	0.18969	28481359
BRCA1	1100	COSM6907422,	urinary_tract	carcinoma	p.P364A	Substitution - Missense	17:43094441-43094441,	NEUTRAL	0.18829	25225064
BRCA1	1100	COSM133664,	breast	carcinoma	p.K38N	Substitution - Missense	17:43115746-43115746,	NEUTRAL	0.1866	22116506
BRCA1	1100	COSM5730331,	breast	other	p.T1249P	Substitution - Missense	17:43091786-43091786,	NEUTRAL	0.18571	26437033
BRCA1	1100	COSM6922310,	lung	carcinoma	p.N1016I	Substitution - Missense	17:43092484-43092484,	NEUTRAL	0.18416	28481359
BRCA1	1100	COSM6904368,	breast	carcinoma	p.E842K	Substitution - Missense	17:43093007-43093007,	NEUTRAL	0.1811	27925203
BRCA1	1100	COSM6955235,	large_intestine	carcinoma	p.L750I	Substitution - Missense	17:43093283-43093283,	NEUTRAL	0.17966	28481359
BRCA1	1100	COSM6951826,	central_nervous_system	glioma	p.D1123N	Substitution - Missense	17:43092164-43092164,	NEUTRAL	0.17653	28481359
BRCA1	1100	COSM6943774,	urinary_tract	carcinoma	p.P1315L	Substitution - Missense	17:43091587-43091587,	NEUTRAL	0.17155	28481359
BRCA1	1100	COSM6963363,	skin	carcinoma	p.E352D	Substitution - Missense	17:43094475-43094475,	NEUTRAL	0.17072	28481359
BRCA1	1100	COSM6968230,	skin	malignant_melanoma	p.I1237L	Substitution - Missense	17:43091822-43091822,	NEUTRAL	0.16975	28481359
BRCA1	1100	COSM6940749,	lung	carcinoma	p.L269F	Substitution - Missense	17:43094724-43094724,	NEUTRAL	0.16629	28481359
BRCA1	1100	COSM33563,	breast	carcinoma	p.G778C	Substitution - Missense	17:43093199-43093199,	NEUTRAL	0.16554	16959974
BRCA1	1100	COSM5575440,	ovary	carcinoma	p.P1562T	Substitution - Missense	17:43071230-43071230,	NEUTRAL	0.16513	25846551
BRCA1	1100	COSM6980775,	prostate	carcinoma	p.N473S	Substitution - Missense	17:43094113-43094113,	NEUTRAL	0.16198	28481359
BRCA1	1100	COSM7325180,	biliary_tract	carcinoma	p.L1558I	Substitution - Missense	17:43074334-43074334,	NEUTRAL	0.15975	29360550
BRCA1	1100	COSM7325180,	biliary_tract	carcinoma	p.L1558I	Substitution - Missense	17:43074334-43074334,	NEUTRAL	0.15975	29360550
BRCA1	1100	COSM6964076,	lung	carcinoma	p.H1244Y	Substitution - Missense	17:43091801-43091801,	NEUTRAL	0.15277	28481359
BRCA1	1100	COSM6964584,	large_intestine	carcinoma	p.G890W	Substitution - Missense	17:43092863-43092863,	NEUTRAL	0.15113	28481359
BRCA1	1100	COSM6944146,	urinary_tract	carcinoma	p.E1490Q	Substitution - Missense	17:43076504-43076504,	NEUTRAL	0.15026	28481359
BRCA1	1100	COSM6944146,	urinary_tract	carcinoma	p.E1490Q	Substitution - Missense	17:43076504-43076504,	NEUTRAL	0.15026	28481359
BRCA1	1100	COSM4066742,	skin	carcinoma	p.S1499F	Substitution - Missense	17:43074510-43074510,	NEUTRAL	0.14306	28481359
BRCA1	1100	COSM1645401,	large_intestine	carcinoma	p.N1067Y	Substitution - Missense	17:43092332-43092332,	NEUTRAL	0.142	23700467
BRCA1	1100	COSM6965200,	urinary_tract	carcinoma	p.D695N	Substitution - Missense	17:43093448-43093448,	NEUTRAL	0.14019	28481359
BRCA1	1100	COSM6946371,	large_intestine	carcinoma	p.S741Y	Substitution - Missense	17:43093309-43093309,	NEUTRAL	0.13857	28481359
BRCA1	1100	COSM6911858,	lung	carcinoma	p.A1308S	Substitution - Missense	17:43091609-43091609,	NEUTRAL	0.13746	28481359
BRCA1	1100	COSM6932046,	central_nervous_system	glioma	p.L471F	Substitution - Missense	17:43094120-43094120,	NEUTRAL	0.13685	28481359
BRCA1	1100	COSM5009557,	large_intestine	carcinoma	p.S335I	Substitution - Missense	17:43094527-43094527,	NEUTRAL	0.13564	24951259
BRCA1	1100	COSM6986490,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.N550H	Substitution - Missense	17:43093883-43093883,	NEUTRAL	0.1301	28481359
BRCA1	1100	COSM5607950,	skin	malignant_melanoma	p.S1241F	Substitution - Missense	17:43091809-43091809,	NEUTRAL	0.12173	26343386
BRCA1	1100	COSM219050,	ovary	carcinoma	p.E836*	Substitution - Nonsense	17:43093025-43093025,	NEUTRAL	0.11594	20606085
BRCA1	1100	COSM6849656,	breast	carcinoma	p.E1373E	Substitution - coding silent	17:43091010-43091010,	NEUTRAL	0.11335	28270497
BRCA1	1100	COSM1577247,	ovary	carcinoma	p.L1276*	Substitution - Nonsense	17:43091704-43091704,	NEUTRAL	0.11244	23633455
BRCA1	1100	COSM6909111,	urinary_tract	carcinoma	p.H1284Y	Substitution - Missense	17:43091681-43091681,	NEUTRAL	0.11141	28481359
BRCA1	1100	COSM3190103,	large_intestine	carcinoma	p.E575K	Substitution - Missense	17:43093808-43093808,	NEUTRAL	0.10995	28481359
BRCA1	1100	COSM6910271,	breast	carcinoma	p.G1825R	Substitution - Missense	17:43045797-43045797,	NEUTRAL	0.10907	28481359
BRCA1	1100	COSM6951202,	breast	carcinoma	p.R951K	Substitution - Missense	17:43092679-43092679,	NEUTRAL	0.10898	28481359
BRCA1	1100	COSM6951007,	urinary_tract	carcinoma	p.E1413K	Substitution - Missense	17:43082524-43082524,	NEUTRAL	0.10761	28481359
BRCA1	1100	COSM6923792,	breast	carcinoma	p.S561F	Substitution - Missense	17:43093849-43093849,	NEUTRAL	0.10757	28481359
BRCA1	1100	COSM95581,	large_intestine	carcinoma	p.E1644*	Substitution - Nonsense	17:43070984-43070984,	NEUTRAL	0.10718	28481359
BRCA1	1100	COSM95581,	lung	carcinoma	p.E1644*	Substitution - Nonsense	17:43070984-43070984,	NEUTRAL	0.10718	20668451
BRCA1	1100	COSM6984614,	endometrium	carcinoma	p.E1112A	Substitution - Missense	17:43092196-43092196,	NEUTRAL	0.10672	28481359
BRCA1	1100	COSM6940989,	urinary_tract	carcinoma	p.D345H	Substitution - Missense	17:43094498-43094498,	NEUTRAL	0.10434	28481359
BRCA1	1100	COSM6920782,	lung	carcinoma	p.E1214D	Substitution - Missense	17:43091889-43091889,	NEUTRAL	0.10421	28481359
BRCA1	1100	COSM4989395,	soft_tissue	haemangioblastoma	p.D693N	Substitution - Missense	17:43093454-43093454,	NEUTRAL	0.10317	25589003
BRCA1	1100	COSM4989395,	soft_tissue	haemangioblastoma	p.D693N	Substitution - Missense	17:43093454-43093454,	NEUTRAL	0.10317	25589003
BRCA1	1100	COSM6976685,	central_nervous_system	glioma	p.P497S	Substitution - Missense	17:43094042-43094042,	NEUTRAL	0.10125	28481359
BRCA1	1100	COSM6928176,	urinary_tract	carcinoma	p.E1185Q	Substitution - Missense	17:43091978-43091978,	NEUTRAL	0.09946	28481359
BRCA1	1100	COSM5575249,	ovary	carcinoma	p.Y777*	Substitution - Nonsense	17:43093200-43093200,	NEUTRAL	0.09751	25846551
BRCA1	1100	COSM219051,	ovary	carcinoma	p.E1609*	Substitution - Nonsense	17:43071089-43071089,	NEUTRAL	0.09579	20606085
BRCA1	1100	COSM6987719,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.I946F	Substitution - Missense	17:43092695-43092695,	NEUTRAL	0.09324	28481359
BRCA1	1100	COSM5009437,	large_intestine	carcinoma	p.R1762G	Substitution - Missense	17:43051111-43051111,	NEUTRAL	0.09311	24951259
BRCA1	1100	COSM93977,	breast	carcinoma	p.I986M	Substitution - Missense	17:43092573-43092573,	NEUTRAL	0.09289	20668451
BRCA1	1100	COSM6929392,	NS	malignant_melanoma	p.S770L	Substitution - Missense	17:43093222-43093222,	NEUTRAL	0.09203	28481359
BRCA1	1100	COSM5575374,	ovary	carcinoma	p.M1008I	Substitution - Missense	17:43092507-43092507,	NEUTRAL	0.0902	25846551
BRCA1	1100	COSM5007993,	large_intestine	carcinoma	p.R979R	Substitution - coding silent	17:43092594-43092594,	NEUTRAL	0.08997	24951259
BRCA1	1100	COSM6944302,	large_intestine	carcinoma	p.K556Q	Substitution - Missense	17:43093865-43093865,	NEUTRAL	0.08484	28481359
BRCA1	1100	COSM3190057,	endometrium	carcinoma	p.E962K	Substitution - Missense	17:43092647-43092647,	NEUTRAL	0.08371	28481359
BRCA1	1100	COSM6944155,	breast	carcinoma	p.R496C	Substitution - Missense	17:43094045-43094045,	NEUTRAL	0.08315	28481359
BRCA1	1100	COSM309513,	lung	carcinoma	p.I1858I	Substitution - coding silent	17:43045696-43045696,	NEUTRAL	0.08211	22941188
BRCA1	1100	COSM6943405,	urinary_tract	carcinoma	p.E250K	Substitution - Missense	17:43094783-43094783,	NEUTRAL	0.08063	28481359
BRCA1	1100	COSM5009291,	large_intestine	carcinoma	p.S1021S	Substitution - coding silent	17:43092468-43092468,	NEUTRAL	0.0803	24951259
BRCA1	1100	COSM6913810,	breast	carcinoma	p.K608N	Substitution - Missense	17:43093707-43093707,	NEUTRAL	0.0776	28481359
BRCA1	1100	COSM5575486,	ovary	carcinoma	p.Q921H	Substitution - Missense	17:43092768-43092768,	NEUTRAL	0.07549	25846551
BRCA1	1100	COSM5575401,	ovary	carcinoma	p.?	Unknown	17:43094868-43094868,	NEUTRAL	0.07194	25846551
BRCA1	1100	COSM6950497,	autonomic_ganglia	neuroblastoma	p.E457*	Substitution - Nonsense	17:43094162-43094162,	NEUTRAL	0.07022	28481359
BRCA1	1100	COSM6971202,	urinary_tract	carcinoma	p.D1546Y	Substitution - Missense	17:43074370-43074370,	NEUTRAL	0.06978	28481359
BRCA1	1100	COSM6980253,	large_intestine	carcinoma	p.Q202R	Substitution - Missense	17:43095911-43095911,	NEUTRAL	0.0672	28481359
BRCA1	1100	COSM6924946,	lung	carcinoma	p.G1543V	Substitution - Missense	17:43074378-43074378,	NEUTRAL	0.06708	28481359
BRCA1	1100	COSM33259,	breast	carcinoma	p.L758F	Substitution - Missense	17:43093257-43093257,	NEUTRAL	0.06614	16959974
BRCA1	1100	COSM6942405,	autonomic_ganglia	neuroblastoma	p.I783L	Substitution - Missense	17:43093184-43093184,	NEUTRAL	0.06602	28481359
BRCA1	1100	COSM5575368,	ovary	carcinoma	p.S1551T	Substitution - Missense	17:43074355-43074355,	NEUTRAL	0.06316	25846551
BRCA1	1100	COSM6946369,	large_intestine	carcinoma	p.K1278Q	Substitution - Missense	17:43091699-43091699,	NEUTRAL	0.06225	28481359
BRCA1	1100	COSM4936462,	urinary_tract	carcinoma	p.A1608T	Substitution - Missense	17:43071092-43071092,	NEUTRAL	0.06047	28481359
BRCA1	1100	COSM6948299,	central_nervous_system	glioma	p.G1371E	Substitution - Missense	17:43091017-43091017,	NEUTRAL	0.05993	28481359
BRCA1	1100	COSM6918674,	skin	carcinoma	p.P1315S	Substitution - Missense	17:43091588-43091588,	NEUTRAL	0.05835	28481359
BRCA1	1100	COSM3755566,	large_intestine	carcinoma	p.L771L	Substitution - coding silent	17:43093220-43093220,	NEUTRAL	0.05772	24951259
BRCA1	1100	COSM3755566,	breast	carcinoma	p.L771L	Substitution - coding silent	17:43093220-43093220,	NEUTRAL	0.05772	28270497
BRCA1	1100	COSM6962805,	central_nervous_system	glioma	p.S242N	Substitution - Missense	17:43094806-43094806,	NEUTRAL	0.0562	28481359
BRCA1	1100	COSM6983858,	salivary_gland	carcinoma	p.S1466I	Substitution - Missense	17:43076575-43076575,	NEUTRAL	0.05608	28481359
BRCA1	1100	COSM6927490,	lung	carcinoma	p.P334S	Substitution - Missense	17:43094531-43094531,	NEUTRAL	0.05557	28481359
BRCA1	1100	COSM5575455,	ovary	carcinoma	p.T1619S	Substitution - Missense	17:43071059-43071059,	NEUTRAL	0.05258	25846551
BRCA1	1100	COSM249516,	kidney	carcinoma	p.Q895R	Substitution - Missense	17:43092847-43092847,	NEUTRAL	0.05154	22138691
BRCA1	1100	COSM35894,	breast	carcinoma	p.S1140G	Substitution - Missense	17:43092113-43092113,	NEUTRAL	0.05141	19593635
BRCA1	1100	COSM6984759,	lung	carcinoma	p.G1624W	Substitution - Missense	17:43071044-43071044,	NEUTRAL	0.05094	28481359
BRCA1	1100	COSM6972019,	biliary_tract	carcinoma	p.S708C	Substitution - Missense	17:43093408-43093408,	NEUTRAL	0.05018	28481359
BRCA1	1100	COSM5010127,	large_intestine	carcinoma	p.L735L	Substitution - coding silent	17:43093326-43093326,	NEUTRAL	0.0501	24951259
BRCA1	1100	COSM3755563,	breast	carcinoma	p.E1038G	Substitution - Missense	17:43092418-43092418,	NEUTRAL	0.05009	28270497
BRCA1	1100	COSM3755563,	thymus	thymoma	p.E1038G	Substitution - Missense	17:43092418-43092418,	NEUTRAL	0.05009	24974848
BRCA1	1100	COSM6929070,	central_nervous_system	glioma	p.S1434N	Substitution - Missense	17:43082460-43082460,	NEUTRAL	0.04749	28481359
BRCA1	1100	COSM6915241,	testis	germ_cell_tumour	p.G535R	Substitution - Missense	17:43093928-43093928,	NEUTRAL	0.04664	28481359
BRCA1	1100	COSM6965466,	salivary_gland	carcinoma	p.L413M	Substitution - Missense	17:43094294-43094294,	NEUTRAL	0.0446	28481359
BRCA1	1100	COSM6947518,	lung	carcinoma	p.P1491L	Substitution - Missense	17:43076500-43076500,	NEUTRAL	0.04459	28481359
BRCA1	1100	COSM6947518,	urinary_tract	carcinoma	p.P1491L	Substitution - Missense	17:43076500-43076500,	NEUTRAL	0.04459	28481359
BRCA1	1100	COSM4990999,	skin	carcinoma	p.L1439F	Substitution - Missense	17:43082446-43082446,	NEUTRAL	0.04416	25589618
BRCA1	1100	COSM5575519,	ovary	carcinoma	p.?	Unknown	17:43074529-43074529,	NEUTRAL	0.04394	25846551
BRCA1	1100	COSM6982900,	breast	carcinoma	p.Q1525H	Substitution - Missense	17:43074431-43074431,	NEUTRAL	0.04328	28481359
BRCA1	1100	COSM93979,	lung	carcinoma	p.V370I	Substitution - Missense	17:43094423-43094423,	NEUTRAL	0.04309	28481359
BRCA1	1100	COSM93979,	breast	carcinoma	p.V370I	Substitution - Missense	17:43094423-43094423,	NEUTRAL	0.04309	20668451
BRCA1	1100	COSM5589839,	kidney	carcinoma	p.P930S	Substitution - Missense	17:43092743-43092743,	NEUTRAL	0.04148	28481359
BRCA1	1100	COSM6956818,	lung	carcinoma	p.V1035D	Substitution - Missense	17:43092427-43092427,	NEUTRAL	0.04117	28481359
BRCA1	1100	COSM4416375,	large_intestine	carcinoma	p.S1436S	Substitution - coding silent	17:43082453-43082453,	NEUTRAL	0.04109	24951259
BRCA1	1100	COSM4883379,	ovary	carcinoma	p.D1582E	Substitution - Missense	17:43071168-43071168,	NEUTRAL	0.0392	25846551
BRCA1	1100	COSM6938515,	large_intestine	carcinoma	p.H399R	Substitution - Missense	17:43094335-43094335,	NEUTRAL	0.03899	28481359
BRCA1	1100	COSM5607952,	skin	malignant_melanoma	p.F958F	Substitution - coding silent	17:43092657-43092657,	NEUTRAL	0.03891	26343386
BRCA1	1100	COSM6923117,	central_nervous_system	glioma	p.V1378I	Substitution - Missense	17:43090997-43090997,	NEUTRAL	0.0382	28481359
BRCA1	1100	COSM5989940,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.S153R	Substitution - Missense	17:43099865-43099865,	NEUTRAL	0.03784	26648538
BRCA1	1100	COSM6915175,	lung	carcinoma	p.R1762M	Substitution - Missense	17:43051110-43051110,	NEUTRAL	0.03728	28481359
BRCA1	1100	COSM3190073,	large_intestine	carcinoma	p.T843A	Substitution - Missense	17:43093004-43093004,	NEUTRAL	0.03695	28481359
BRCA1	1100	COSM5575245,	ovary	carcinoma	p.W1508C	Substitution - Missense	17:43074482-43074482,	NEUTRAL	0.03582	25846551
BRCA1	1100	COSM6967916,	lung	carcinoma	p.N1488S	Substitution - Missense	17:43076509-43076509,	NEUTRAL	0.03457	28481359
BRCA1	1100	COSM6977429,	pancreas	carcinoma	p.P568T	Substitution - Missense	17:43093829-43093829,	NEUTRAL	0.03452	28481359
BRCA1	1100	COSM6984047,	NS	malignant_melanoma	p.G1515E	Substitution - Missense	17:43074462-43074462,	NEUTRAL	0.03418	28481359
BRCA1	1100	COSM7325173,	biliary_tract	carcinoma	p.S434N	Substitution - Missense	17:43094230-43094230,	NEUTRAL	0.03308	29360550
BRCA1	1100	COSM6911765,	central_nervous_system	glioma	p.S1360N	Substitution - Missense	17:43091452-43091452,	NEUTRAL	0.03307	28481359
BRCA1	1100	COSM1246204,	urinary_tract	carcinoma	p.R841W	Substitution - Missense	17:43093010-43093010,	NEUTRAL	0.03177	28481359
BRCA1	1100	COSM1246204,	prostate	carcinoma	p.R841W	Substitution - Missense	17:43093010-43093010,	NEUTRAL	0.03177	28481359
BRCA1	1100	COSM3755560,	thymus	thymoma	p.S1613G	Substitution - Missense	17:43071077-43071077,	NEUTRAL	0.03114	24974848
BRCA1	1100	COSM3755560,	large_intestine	carcinoma	p.S1613G	Substitution - Missense	17:43071077-43071077,	NEUTRAL	0.03114	24951259
BRCA1	1100	COSM3755560,	breast	carcinoma	p.S1613G	Substitution - Missense	17:43071077-43071077,	NEUTRAL	0.03114	28270497
BRCA1	1100	COSM6974300,	large_intestine	carcinoma	p.I1680V	Substitution - Missense	17:43067644-43067644,	NEUTRAL	0.03095	28481359
BRCA1	1100	COSM4604945,	upper_aerodigestive_tract	carcinoma	p.K912N	Substitution - Missense	17:43092795-43092795,	NEUTRAL	0.0306	25056374
BRCA1	1100	COSM6960597,	lung	carcinoma	p.G200V	Substitution - Missense	17:43095917-43095917,	NEUTRAL	0.03057	28481359
BRCA1	1100	COSM6845287,	vulva	in_situ_neoplasm	p.M1008I	Substitution - Missense	17:43092507-43092507,	NEUTRAL	0.03023	27834349
BRCA1	1100	COSM6845287,	vulva	in_situ_neoplasm	p.M1008I	Substitution - Missense	17:43092507-43092507,	NEUTRAL	0.03023	27834349
BRCA1	1100	COSM5575442,	ovary	carcinoma	p.C636F	Substitution - Missense	17:43093624-43093624,	NEUTRAL	0.028	25846551
BRCA1	1100	COSM6907057,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.F486L	Substitution - Missense	17:43094075-43094075,	NEUTRAL	0.02477	28481359
BRCA1	1100	COSM6907057,	endometrium	carcinoma	p.F486L	Substitution - Missense	17:43094075-43094075,	NEUTRAL	0.02477	29420467
BRCA1	1100	COSM6981661,	large_intestine	carcinoma	p.G1803V	Substitution - Missense	17:43047702-43047702,	NEUTRAL	0.02422	28481359
BRCA1	1100	COSM6959551,	central_nervous_system	glioma	p.G1138E	Substitution - Missense	17:43092118-43092118,	NEUTRAL	0.02402	28481359
BRCA1	1100	COSM5607954,	skin	malignant_melanoma	p.E1635E	Substitution - coding silent	17:43071009-43071009,	NEUTRAL	0.02378	26343386
BRCA1	1100	COSM5575247,	ovary	carcinoma	p.Y831F	Substitution - Missense	17:43093039-43093039,	NEUTRAL	0.02357	25846551
BRCA1	1100	COSM6977845,	prostate	carcinoma	p.T1485S	Substitution - Missense	17:43076518-43076518,	NEUTRAL	0.02179	28481359
BRCA1	1100	COSM6914389,	skin	carcinoma	p.T236I	Substitution - Missense	17:43094824-43094824,	NEUTRAL	0.01787	28481359
BRCA1	1100	COSM148277,	soft_tissue	haemangioblastoma	p.K1183R	Substitution - Missense	17:43091983-43091983,	NEUTRAL	0.01713	25589003
BRCA1	1100	COSM148277,	soft_tissue	haemangioblastoma	p.K1183R	Substitution - Missense	17:43091983-43091983,	NEUTRAL	0.01713	25589003
BRCA1	1100	COSM148277,	soft_tissue	haemangioblastoma	p.K1183R	Substitution - Missense	17:43091983-43091983,	NEUTRAL	0.01713	25589003
BRCA1	1100	COSM148277,	soft_tissue	haemangioblastoma	p.K1183R	Substitution - Missense	17:43091983-43091983,	NEUTRAL	0.01713	25589003
BRCA1	1100	COSM148277,	soft_tissue	haemangioblastoma	p.K1183R	Substitution - Missense	17:43091983-43091983,	NEUTRAL	0.01713	25589003
BRCA1	1100	COSM148277,	breast	carcinoma	p.K1183R	Substitution - Missense	17:43091983-43091983,	NEUTRAL	0.01713	28270497
BRCA1	1100	COSM148277,	soft_tissue	haemangioblastoma	p.K1183R	Substitution - Missense	17:43091983-43091983,	NEUTRAL	0.01713	25589003
BRCA1	1100	COSM148277,	soft_tissue	haemangioblastoma	p.K1183R	Substitution - Missense	17:43091983-43091983,	NEUTRAL	0.01713	25589003
BRCA1	1100	COSM148277,	soft_tissue	haemangioblastoma	p.K1183R	Substitution - Missense	17:43091983-43091983,	NEUTRAL	0.01713	25589003
BRCA1	1100	COSM148277,	large_intestine	carcinoma	p.K1183R	Substitution - Missense	17:43091983-43091983,	NEUTRAL	0.01713	24951259
BRCA1	1100	COSM148277,	soft_tissue	haemangioblastoma	p.K1183R	Substitution - Missense	17:43091983-43091983,	NEUTRAL	0.01713	25589003
BRCA1	1100	COSM148277,	soft_tissue	haemangioblastoma	p.K1183R	Substitution - Missense	17:43091983-43091983,	NEUTRAL	0.01713	25589003
BRCA1	1100	COSM148277,	soft_tissue	haemangioblastoma	p.K1183R	Substitution - Missense	17:43091983-43091983,	NEUTRAL	0.01713	25589003
BRCA1	1100	COSM148277,	soft_tissue	haemangioblastoma	p.K1183R	Substitution - Missense	17:43091983-43091983,	NEUTRAL	0.01713	25589003
BRCA1	1100	COSM148277,	soft_tissue	haemangioblastoma	p.K1183R	Substitution - Missense	17:43091983-43091983,	NEUTRAL	0.01713	25589003
BRCA1	1100	COSM148277,	soft_tissue	haemangioblastoma	p.K1183R	Substitution - Missense	17:43091983-43091983,	NEUTRAL	0.01713	25589003
BRCA1	1100	COSM148278,	soft_tissue	haemangioblastoma	p.P871L	Substitution - Missense	17:43092919-43092919,	NEUTRAL	0.01658	25589003
BRCA1	1100	COSM148278,	soft_tissue	haemangioblastoma	p.P871L	Substitution - Missense	17:43092919-43092919,	NEUTRAL	0.01658	25589003
BRCA1	1100	COSM148278,	soft_tissue	haemangioblastoma	p.P871L	Substitution - Missense	17:43092919-43092919,	NEUTRAL	0.01658	25589003
BRCA1	1100	COSM148278,	soft_tissue	haemangioblastoma	p.P871L	Substitution - Missense	17:43092919-43092919,	NEUTRAL	0.01658	25589003
BRCA1	1100	COSM148278,	soft_tissue	haemangioblastoma	p.P871L	Substitution - Missense	17:43092919-43092919,	NEUTRAL	0.01658	25589003
BRCA1	1100	COSM148278,	breast	carcinoma	p.P871L	Substitution - Missense	17:43092919-43092919,	NEUTRAL	0.01658	28270497
BRCA1	1100	COSM148278,	soft_tissue	haemangioblastoma	p.P871L	Substitution - Missense	17:43092919-43092919,	NEUTRAL	0.01658	25589003
BRCA1	1100	COSM148278,	soft_tissue	haemangioblastoma	p.P871L	Substitution - Missense	17:43092919-43092919,	NEUTRAL	0.01658	25589003
BRCA1	1100	COSM148278,	large_intestine	carcinoma	p.P871L	Substitution - Missense	17:43092919-43092919,	NEUTRAL	0.01658	24951259
BRCA1	1100	COSM148278,	soft_tissue	haemangioblastoma	p.P871L	Substitution - Missense	17:43092919-43092919,	NEUTRAL	0.01658	25589003
BRCA1	1100	COSM148278,	soft_tissue	haemangioblastoma	p.P871L	Substitution - Missense	17:43092919-43092919,	NEUTRAL	0.01658	25589003
BRCA1	1100	COSM148278,	soft_tissue	haemangioblastoma	p.P871L	Substitution - Missense	17:43092919-43092919,	NEUTRAL	0.01658	25589003
BRCA1	1100	COSM148278,	soft_tissue	haemangioblastoma	p.P871L	Substitution - Missense	17:43092919-43092919,	NEUTRAL	0.01658	25589003
BRCA1	1100	COSM148278,	soft_tissue	haemangioblastoma	p.P871L	Substitution - Missense	17:43092919-43092919,	NEUTRAL	0.01658	25589003
BRCA1	1100	COSM148278,	soft_tissue	haemangioblastoma	p.P871L	Substitution - Missense	17:43092919-43092919,	NEUTRAL	0.01658	25589003
BRCA1	1100	COSM148278,	soft_tissue	haemangioblastoma	p.P871L	Substitution - Missense	17:43092919-43092919,	NEUTRAL	0.01658	25589003
BRCA1	1100	COSM5575361,	ovary	carcinoma	p.V1493E	Substitution - Missense	17:43076494-43076494,	NEUTRAL	0.01519	25846551
BRCA1	1100	COSM1168835,	bone	osteosarcoma	p.T539M	Substitution - Missense	17:43093915-43093915,	NEUTRAL	0.01366	27499911
BRCA1	1100	COSM6612502,	large_intestine	carcinoma	p.L1260V	Substitution - Missense	17:43091753-43091753,	NEUTRAL	0.01236	28481359
BRCA1	1100	COSM6952888,	pancreas	carcinoma	p.Y1625C	Substitution - Missense	17:43071040-43071040,	NEUTRAL	0.0123	28481359
BRCA1	1100	COSM6976683,	central_nervous_system	glioma	p.E1540K	Substitution - Missense	17:43074388-43074388,	NEUTRAL	0.01172	28481359
BRCA1	1100	COSM6913715,	central_nervous_system	glioma	p.G200R	Substitution - Missense	17:43095918-43095918,	NEUTRAL	0.00897	28481359
BRCA1	1100	COSM6932044,	central_nervous_system	glioma	p.M751I	Substitution - Missense	17:43093278-43093278,	NEUTRAL	0.00897	28481359
BRCA1	1100	COSM6938826,	large_intestine	carcinoma	p.I171T	Substitution - Missense	17:43099810-43099810,	NEUTRAL	0.00887	28481359
BRCA1	1100	COSM1521479,	large_intestine	carcinoma	p.A622A	Substitution - coding silent	17:43093665-43093665,	NEUTRAL	0.00681	24951259
BRCA1	1100	COSM6971572,	lung	carcinoma	p.T922A	Substitution - Missense	17:43092767-43092767,	NEUTRAL	0.00579	28481359
BRCA1	1100	COSM148280,	soft_tissue	haemangioblastoma	p.S694S	Substitution - coding silent	17:43093449-43093449,	NEUTRAL	0.00463	25589003
BRCA1	1100	COSM148280,	soft_tissue	haemangioblastoma	p.S694S	Substitution - coding silent	17:43093449-43093449,	NEUTRAL	0.00463	25589003
BRCA1	1100	COSM148280,	soft_tissue	haemangioblastoma	p.S694S	Substitution - coding silent	17:43093449-43093449,	NEUTRAL	0.00463	25589003
BRCA1	1100	COSM148280,	soft_tissue	haemangioblastoma	p.S694S	Substitution - coding silent	17:43093449-43093449,	NEUTRAL	0.00463	25589003
BRCA1	1100	COSM148280,	soft_tissue	haemangioblastoma	p.S694S	Substitution - coding silent	17:43093449-43093449,	NEUTRAL	0.00463	25589003
BRCA1	1100	COSM148280,	soft_tissue	haemangioblastoma	p.S694S	Substitution - coding silent	17:43093449-43093449,	NEUTRAL	0.00463	25589003
BRCA1	1100	COSM148280,	soft_tissue	haemangioblastoma	p.S694S	Substitution - coding silent	17:43093449-43093449,	NEUTRAL	0.00463	25589003
BRCA1	1100	COSM148280,	soft_tissue	haemangioblastoma	p.S694S	Substitution - coding silent	17:43093449-43093449,	NEUTRAL	0.00463	25589003
BRCA1	1100	COSM148280,	soft_tissue	haemangioblastoma	p.S694S	Substitution - coding silent	17:43093449-43093449,	NEUTRAL	0.00463	25589003
BRCA1	1100	COSM148280,	soft_tissue	haemangioblastoma	p.S694S	Substitution - coding silent	17:43093449-43093449,	NEUTRAL	0.00463	25589003
BRCA1	1100	COSM148280,	soft_tissue	haemangioblastoma	p.S694S	Substitution - coding silent	17:43093449-43093449,	NEUTRAL	0.00463	25589003
BRCA1	1100	COSM148280,	soft_tissue	haemangioblastoma	p.S694S	Substitution - coding silent	17:43093449-43093449,	NEUTRAL	0.00463	25589003
BRCA1	1100	COSM148280,	large_intestine	carcinoma	p.S694S	Substitution - coding silent	17:43093449-43093449,	NEUTRAL	0.00463	24951259
BRCA1	1100	COSM148280,	breast	carcinoma	p.S694S	Substitution - coding silent	17:43093449-43093449,	NEUTRAL	0.00463	28270497
BRCA1	1100	COSM148280,	soft_tissue	haemangioblastoma	p.S694S	Substitution - coding silent	17:43093449-43093449,	NEUTRAL	0.00463	25589003
BRCA1	1100	COSM6941994,	large_intestine	carcinoma	p.S1448N	Substitution - Missense	17:43082418-43082418,	NEUTRAL	0.00445	28481359
BRCA1	1100	COSM5743853,	thyroid	adenoma-nodule-goitre	p.R496H	Substitution - Missense	17:43094044-43094044,	NEUTRAL	0.00389	28481359
BRCA1	1100	COSM5008016,	large_intestine	carcinoma	p.R332Q	Substitution - Missense	17:43094536-43094536,	NEUTRAL	0.00324	24951259
BRCA1	1100	COSM5010125,	large_intestine	carcinoma	p.S1587P	Substitution - Missense	17:43071155-43071155,	NEUTRAL	0.00177	24951259
BRCA1	1100	COSM5575550,	ovary	carcinoma	p.D1506N	Substitution - Missense	17:43074490-43074490,	NEUTRAL	0.00168	25846551
BRCA1	1100	COSM6943772,	urinary_tract	carcinoma	p.E1478Q	Substitution - Missense	17:43076540-43076540,	NEUTRAL	0.00082	28481359
BRCA1	1100	COSM5415231,	endometrium	carcinoma	p.?fs*?	Deletion - Frameshift	Info_not_available	Info_not_available	Info_not_available	25233892
BRCA1	1100	COSM4603640,	pancreas	carcinoma	p.?, p.E1250fs*8, p.E23fs*17, p.W1508*	Frameshift, Substitution - Nonsense, Unknown	Info_not_available	Info_not_available	Info_not_available	25266736
BRCA1	1100	COSM4984808,	lung	carcinoma	p.E1011K	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	25567908
BRCA1	1100	COSM3190163,	soft_tissue	haemangioblastoma	p.E23fs*17	Deletion - Frameshift	17:43124028-43124029,	Info_not_available	Info_not_available	25589003
BRCA1	1100	COSM5032207,	lung	carcinoma	p.A224S, p.K223N	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	25922291
BRCA1	1100	COSM6057040,	lung	carcinoma	p.E648Q	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	25971939
BRCA1	1100	COSM6023966,	NS	carcinoma	p.C39fs*1, p.Q1756fs*74	Frameshift	Info_not_available	Info_not_available	Info_not_available	26182302
BRCA1	1100	COSM6005480,	breast	carcinoma, other	p.D1505fs*43	Deletion - Frameshift	17:43074494-43074494,	Info_not_available	Info_not_available	26806567
BRCA1	1100	COSM5702555,	ovary	germ_cell_tumour	p.L502fs*2	Deletion - Frameshift	17:43094023-43094027,	Info_not_available	Info_not_available	26822237
BRCA1	1100	COSM6022878,	lung	carcinoma	p.C903*	Substitution - Nonsense	Info_not_available	Info_not_available	Info_not_available	27528220
BRCA1	1100	COSM5985660,	lung	carcinoma	p.K1702E	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	27588476
BRCA1	1100	COSM6904461,	upper_aerodigestive_tract	carcinoma	p.D366H	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	28493366
BRCA1	1100	COSM6904547,	breast	carcinoma	p.I492L, p.Q563H	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	28921573
BRCA1	1100	COSM4166524,	upper_aerodigestive_tract	carcinoma	p.?	Unknown	Info_not_available	Info_not_available	Info_not_available	28961834
BRCA1	1100	COSM6865932,	skin	malignant_melanoma	p.R841W	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	29264386
BRCA1	1100	COSM6997553,	liver	carcinoma	p.G511G	Substitution - coding silent	Info_not_available	Info_not_available	Info_not_available	29487225
BRCA1	1100	COSM23923,	ovary	carcinoma	p.A1814fs*20	Deletion - Frameshift	17:43047670-43047670,	Info_not_available	Info_not_available	7795636
BRCA1	1100	COSM24529,	ovary	carcinoma	p.Q12fs*5, p.S1796fs*34	Insertion - Frameshift	17:43124064-43124065,	Info_not_available	Info_not_available	7795652
BRCA1	1100	COSM23948,	ovary	carcinoma	p.E730*, p.G817fs*29, p.Q1420*, p.R1835*, p.V757fs*8, p.Y655fs*18	Deletion - Frameshift, Insertion - Frameshift, Substitution - Nonsense	17:43093570-43093571,	Info_not_available	Info_not_available	9796975
BRCA1	1100	COSM4387488,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.0	Whole gene deletion	Info_not_available	Info_not_available	Info_not_available	24997557
BRCA1	1100	COSM23931,	endometrium	carcinoma	p.K1183fs*4	Deletion - Frameshift	17:43091982-43091983,	Info_not_available	Info_not_available	10451700
BRCA1	1100	COSM23934,	breast	carcinoma	p.I925fs*13	Insertion - Frameshift	17:43092757-43092758,	Info_not_available	Info_not_available	10467410
BRCA1	1100	COSM24626,	ovary	carcinoma	p.F869fs*35	Insertion - Frameshift	17:43092926-43092927,	Info_not_available	Info_not_available	10686936
BRCA1	1100	COSM23932,	ovary	carcinoma	p.C1146fs*8	Deletion - Frameshift	17:43092092-43092095,	Info_not_available	Info_not_available	11240689
BRCA1	1100	COSM23959,	breast	carcinoma	p.E1288fs*19	Deletion - Frameshift	17:43091669-43091669,	Info_not_available	Info_not_available	15712267
BRCA1	1100	COSM35893,	breast	carcinoma	p.E23fs*17, p.P724fs*12, p.Q1756fs*74	Deletion - Frameshift, Insertion - Frameshift	17:43124030-43124031,	Info_not_available	Info_not_available	19593635
BRCA1	1100	COSM219055,	ovary	carcinoma	p.?, p.E29*, p.G1738R, p.H816fs*3, p.K654fs*47, p.N287fs*6	Deletion - Frameshift, Substitution - Missense, Substitution - Nonsense, Unknown	17:43094668-43094672,	Info_not_available	Info_not_available	20606085
BRCA1	1100	COSM1666857,	ovary	carcinoma	p.K1254fs*11, p.V1176fs*34	Deletion - Frameshift	17:43092005-43092005,	Info_not_available	Info_not_available	23633455
BRCA1	1100	COSM1666627,	ovary	carcinoma	p.A17fs*14, p.E23fs*17, p.M1775fs*54, p.Q1756fs*74, p.Q1756fs*75, p.Y1522*	Frameshift, Substitution - Nonsense	Info_not_available	Info_not_available	Info_not_available	23791828
BRCA1	1100	COSM1666622,	biliary_tract	carcinoma	p.Q1756fs*74	Frameshift	Info_not_available	Info_not_available	Info_not_available	24563076
BRCA1	1100	COSM4603914,	upper_aerodigestive_tract	carcinoma	p.V83fs*2	Insertion - Frameshift	17:43104922-43104923,	Info_not_available	Info_not_available	25056374
BRCA1	1100	COSM4166524,	breast	carcinoma	p.?	Unknown	Info_not_available	Info_not_available	Info_not_available	24849582
BRCA1	1100	COSM4172552,	skin	malignant_melanoma	p.?, p.P938S	Substitution - Missense, Unknown	Info_not_available	Info_not_available	Info_not_available	24628946
BRCA1	1100	COSM4766055,	breast	carcinoma	p.S1796fs*34	Insertion - Frameshift	17:43049141-43049142,	Info_not_available	Info_not_available	24185510
BRCA1	1100	COSM5881439,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.R163G	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	24150215
BRCA1	1100	COSM3517885,	skin	carcinoma	p.P985L	Substitution - Missense	17:43092577-43092577,	Info_not_available	0.69524	25589618
BRCA1	1100	COSM6444637,	endometrium	carcinoma	p.I1568S	Substitution - Missense	17:43071211-43071211,	Info_not_available	0.67445	27159395
BRCA1	1100	COSM6906633,	urinary_tract	carcinoma	p.R1347T	Substitution - Missense	17:43091491-43091491,	Info_not_available	0.66658	29420467
BRCA1	1100	COSM6019339,	lung	carcinoma	p.E1346K	Substitution - Missense	17:43091495-43091495,	Info_not_available	0.66017	27694386
BRCA1	1100	COSM5607956,	skin	malignant_melanoma	p.V271V	Substitution - coding silent	17:43094718-43094718,	Info_not_available	0.61579	26343386
BRCA1	1100	COSM23941,	breast	carcinoma	p.?	Unknown	17:43124099-43124099,	Info_not_available	0.56487	9665150
BRCA1	1100	COSM5575476,	ovary	carcinoma	p.K893fs*107, p.Q921L, p.R446fs*9	Deletion - Frameshift, Substitution - Missense	17:43094195-43094196,	Info_not_available	0.55798, Info_not_available	25846551
BRCA1	1100	COSM133667,	breast	carcinoma	p.C64fs*1, p.G275D, p.K309Q	Deletion - Frameshift, Substitution - Missense	17:43106456-43106477,	Info_not_available	0.55347, .67357, Info_not_available	22116506
BRCA1	1100	COSM6024027,	ovary	carcinoma	p.Q210*	Substitution - Nonsense	17:43095888-43095888,	Info_not_available	0.53112	27533253
BRCA1	1100	COSM85905,	breast	carcinoma	p.S451*	Substitution - Nonsense	17:43094179-43094179,	Info_not_available	0.52772	21233401
BRCA1	1100	COSM5009494,	large_intestine	carcinoma	p.E143K	Substitution - Missense	17:43104136-43104136,	Info_not_available	0.52521	24951259
BRCA1	1100	COSM979733,	biliary_tract, breast, central_nervous_system, endometrium, eye, haematopoietic_and_lymphoid_tissue, large_intestine, lung, ovary, pancreas, prostate, skin, soft_tissue, stomach, thyroid, upper_aerodigestive_tract, urinary_tract	carcinoma, glioma, leiomyosarcoma, lymphoid_neoplasm, malignant_melanoma	p.?, p.E1013fs*4, p.E1219fs*12, p.E1258*, p.E1258D, p.E1451*, p.E23fs*18, p.E597*, p.E686fs*1, p.E729fs*10, p.E75fs*13, p.G1371fs*4, p.G1801fs*33, p.G911fs*89, p.I1723V, p.I986fs*14, p.K1079fs*2, p.K339fs*2, p.K654fs*47, p.L1317fs*1, p.L1517V, p.L1764fs*1, p.L290fs*8, p.L358fs*13, p.L666I, p.M1663V, p.M1728fs*2, p.N567fs*16, p.P1190F, p.P1192F, p.P634S, p.Q1240E, p.Q1240L, p.Q1756*, p.Q210fs*6, p.R1347T, p.R296K, p.R71fs*10, p.R7_E9>Q, p.S1497P, p.S1569G, p.S886fs*16, p.T464fs*11, p.V1654fs*4, p.V1792L, p.Y655fs*18	Complex - deletion inframe, Complex - frameshift, Deletion - Frameshift, Insertion - Frameshift, Substitution - Missense, Substitution - Nonsense, Unknown	17:43124072-43124077,	Info_not_available	0.50432, .51501, .51649, .52623, .56306, .57502, .58901, .59178, .60261, .62766, .63384, .64677, .65418, .66658, .6726, .67974, Info_not_available	28481359
BRCA1	1100	COSM93976,	breast	carcinoma	p.E1011K	Substitution - Missense	17:43092500-43092500,	Info_not_available	0.50284	20668451
BRCA1	1100	COSM7325201,	biliary_tract	carcinoma	p.L1676F	Substitution - Missense	17:43067654-43067654,	Info_not_available	0.50154	29360550