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Collapse Statistics
226 human active and 11 inactive phosphatases in total;
194 phosphatases have substrate data;
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305 protein substrates;
89 non-protein substrates;
1114 dephosphorylation interactions;
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213 KEGG pathways;
206 NCI Nature PID pathways
560 Reactome pathways;
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last update: 18 Feb, 2016

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p53

Gene Name TP53 (QuickGO)

PDB ID: 1A1U
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SynonymsTP53 P53
Protein Namep53
Alternative Name(s)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Protein FamilyP53 family
EntrezGene ID7157
UniProt AC (Human)P04637 (protein sequence)
Enzyme ClassN/A
Molecular Weight43653
Protein Length393
Protein DomainInterPro | Pfam3D Structure * PDB | PDBe | DrugPort
* ModBase | SwissModel
Localization (UniProt annotation)Cytoplasm. Nucleus. Nucleus > PML body. Endoplasmic reticulum. Nucleus. Cytoplasm. Cytoplasm.
Gene ExpressionGene Expression Atlas Function and DiseaseOMIM
Protein-protein Interaction Database STRING | IntAct | MINT
Kinase Database Phospho.ELM | PhosphoSite | NetworKIN
Function (UniProt annotation)
FUNCTION: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.
Catalytic Activity (UniProt annotation)
N/A
Protein Sequence
MEEPQSDPSV EPPLSQETFS DLWKLLPENN VLSPLPSQAM DDLMLSPDDI EQWFTEDPGP DEAPRMPEAA PPVAPAPAAP TPAAPAPAPS WPLSSSVPSQ KTYQGSYGFR LGFLHSGTAK SVTCTYSPAL NKMFCQLAKT CPVQLWVDST PPPGTRVRAM AIYKQSQHMT EVVRRCPHHE RCSDSDGLAP PQHLIRVEGN LRVEYLDDRN TFRHSVVVPY EPPEVGSDCT TIHYNYMCNS SCMGGMNRRP ILTIITLEDS SGNLLGRNSF EVRVCACPGR DRRTEEENLR KKGEPHHELP PGSTKRALPN NTSSSPQPKK KPLDGEYFTL QIRGRERFEM FRELNEALEL KDAQAGKEPG GSRAHSSHLK SKKGQSTSRH KKLMFKTEGP DSD
ELM motif
DEG_MDM2_1Motif found in p53 family members which confers binding to the N-terminal domain of MDM2.
DOC_CYCLIN_1Substrate recognition site that interacts with cyclin and thereby increases phosphorylation by cyclin/cdk complexes. Predicted proteins should have a CDK phosphorylation site. Also used by cyclin/cdk inhibitors.
DOC_USP7_1The USP7 NTD domain binding motif variant based on the MDM2 and P53 interactions.
DOC_WW_Pin1_4The Class IV WW domain interaction motif is recognised primarily by the Pin1 phosphorylation-dependent prolyl isomerase.
MOD_CK1_1CK1 phosphorylation site
MOD_GSK3_1GSK3 phosphorylation recognition site
MOD_PIKK_1(ST)Q motif which is phosphorylated by PIKK family members.
MOD_SUMOMotif recognised for modification by SUMO-1
TRG_NES_CRM1_1Some proteins re-exported from the nucleus contain a Leucine-rich nuclear export signal (NES) binding to the CRM1 exportin protein.
TRG_NLS_Bipartite_1Bipartite variant of the classical basically charged NLS.
Gene Ontology
GO:0005524ATP binding
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0042771DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
GO:0006978DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0000739DNA strand annealing activity
GO:0006983ER overload response
GO:0016605PML body
GO:0001085RNA polymerase II transcription factor binding
GO:0007265Ras protein signal transduction
GO:0008635activation of caspase activity by cytochrome c
GO:0006284base-excision repair
GO:0007596blood coagulation
GO:0007050cell cycle arrest
GO:0030154cell differentiation
GO:0008283cell proliferation
GO:0034613cellular protein localization
GO:0034644cellular response to UV
GO:0035690cellular response to drug
GO:0042149cellular response to glucose starvation
GO:0071456cellular response to hypoxia
GO:0071479cellular response to ionizing radiation
GO:0051087chaperone binding
GO:0003682chromatin binding
GO:0005507copper ion binding
GO:0005737cytoplasm
GO:0005829cytosol
GO:0003684damaged DNA binding
GO:0008340determination of adult lifespan
GO:0005783endoplasmic reticulum
GO:0035035histone acetyltransferase binding
GO:0005626insoluble fraction
GO:0044419interspecies interaction between organisms
GO:0005739mitochondrion
GO:0043066negative regulation of apoptosis
GO:0030308negative regulation of cell growth
GO:0008285negative regulation of cell proliferation
GO:0051097negative regulation of helicase activity
GO:0000122negative regulation of transcription from RNA polymerase II promoter
GO:0000790nuclear chromatin
GO:0016363nuclear matrix
GO:0005730nucleolus
GO:0006289nucleotide-excision repair
GO:0005634nucleus
GO:0090403oxidative stress-induced premature senescence
GO:0002039p53 binding
GO:0031065positive regulation of histone deacetylation
GO:0043525positive regulation of neuron apoptosis
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation
GO:2000379positive regulation of reactive oxygen species metabolic process
GO:0070245positive regulation of thymocyte apoptosis
GO:0045944positive regulation of transcription from RNA polymerase II promoter
GO:0002020protease binding
GO:0047485protein N-terminus binding
GO:0005515protein binding
GO:0043234protein complex
GO:0046982protein heterodimerization activity
GO:0019901protein kinase binding
GO:0008104protein localization
GO:0051721protein phosphatase 2A binding
GO:0051262protein tetramerization
GO:0046902regulation of mitochondrial membrane permeability
GO:0005657replication fork
GO:0090399replicative senescence
GO:0010165response to X-ray
GO:0046677response to antibiotic
GO:0010332response to gamma radiation
GO:0003700sequence-specific DNA binding transcription factor activity
GO:0044212transcription regulatory region DNA binding
GO:0016564transcription repressor activity
GO:0031625ubiquitin protein ligase binding
GO:0008270zinc ion binding

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