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Collapse Statistics
226 human active and 11 inactive phosphatases in total;
194 phosphatases have substrate data;
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305 protein substrates;
89 non-protein substrates;
1114 dephosphorylation interactions;
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213 KEGG pathways;
206 NCI Nature PID pathways
560 Reactome pathways;
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last update: 18 Feb, 2016

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GR

Gene Name NR3C1 (QuickGO)

PDB ID: 1M2Z
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SynonymsNR3C1 GRL
Protein NameGR
Alternative Name(s)
Glucocorticoid receptor (GR) (Nuclear receptor subfamily 3 group C member 1)
Protein FamilyNuclear hormone receptor family, NR3 subfamily
EntrezGene ID2908
UniProt AC (Human)P04150 (protein sequence)
Enzyme ClassN/A
Molecular Weight85659
Protein Length777
Protein DomainInterPro | Pfam3D Structure * PDB | PDBe | DrugPort
* ModBase | SwissModel
Localization (UniProt annotation)Cytoplasm. Nucleus. Nucleus.
Gene ExpressionGene Expression Atlas Function and DiseaseOMIM
Protein-protein Interaction Database STRING | IntAct | MINT
Kinase Database Phospho.ELM | PhosphoSite | NetworKIN
Function (UniProt annotation)
FUNCTION: Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE) and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation. Involved in nuclear translocation (By similarity).
Catalytic Activity (UniProt annotation)
N/A
Protein Sequence
MDSKESLTPG REENPSSVLA QERGDVMDFY KTLRGGATVK VSASSPSLAV ASQSDSKQRR LLVDFPKGSV SNAQQPDLSK AVSLSMGLYM GETETKVMGN DLGFPQQGQI SLSSGETDLK LLEESIANLN RSTSVPENPK SSASTAVSAA PTEKEFPKTH SDVSSEQQHL KGQTGTNGGN VKLYTTDQST FDILQDLEFS SGSPGKETNE SPWRSDLLID ENCLLSPLAG EDDSFLLEGN SNEDCKPLIL PDTKPKIKDN GDLVLSSPSN VTLPQVKTEK EDFIELCTPG VIKQEKLGTV YCQASFPGAN IIGNKMSAIS VHGVSTSGGQ MYHYDMNTAS LSQQQDQKPI FNVIPPIPVG SENWNRCQGS GDDNLTSLGT LNFPGRTVFS NGYSSPSMRP DVSSPPSSSS TATTGPPPKL CLVCSDEASG CHYGVLTCGS CKVFFKRAVE GQHNYLCAGR NDCIIDKIRR KNCPACRYRK CLQAGMNLEA RKTKKKIKGI QQATTGVSQE TSENPGNKTI VPATLPQLTP TLVSLLEVIE PEVLYAGYDS SVPDSTWRIM TTLNMLGGRQ VIAAVKWAKA IPGFRNLHLD DQMTLLQYSW MFLMAFALGW RSYRQSSANL LCFAPDLIIN EQRMTLPCMY DQCKHMLYVS SELHRLQVSY EEYLCMKTLL LLSSVPKDGL KSQELFDEIR MTYIKELGKA IVKREGNSSQ NWQRFYQLTK LLDSMHEVVE NLLNYCFQTF LDKTMSIEFP EMLAEIITNQ IPKYSNGNIK KLLFHQK
ELM motif
MOD_SUMOMotif recognised for modification by SUMO-1
Gene Ontology
GO:0016568chromatin modification
GO:0004883glucocorticoid receptor activity
GO:0005759mitochondrial matrix
GO:0005654nucleoplasm
GO:0005515protein binding
GO:0034339regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor
GO:0051789response to protein stimulus
GO:0043565sequence-specific DNA binding
GO:0003700sequence-specific DNA binding transcription factor activity
GO:0005496steroid binding
GO:0006366transcription from RNA polymerase II promoter
GO:0008270zinc ion binding

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