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Collapse Statistics
226 human active and 11 inactive phosphatases in total;
194 phosphatases have substrate data;
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305 protein substrates;
89 non-protein substrates;
1114 dephosphorylation interactions;
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213 KEGG pathways;
206 NCI Nature PID pathways
560 Reactome pathways;
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last update: 18 Feb, 2016

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TPTE2

Gene Name TPTE2 (QuickGO)SynonymsTPTE2 TPIP
Protein NamePhosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2
Alternative name(s)
Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2 (EC 3.1.3.67) (Lipid phosphatase TPIP) (TPTE and PTEN homologous inositol lipid phosphatase)
Ensembl Gene IDENSG00000132958EntrezGene ID93492
UniProt AC (Human)Q6XPS3 (protein sequence)Enzyme ClassEC 3.1.3.67 (BRENDA )
Molecular Weight61112Protein Length522
Phosphatase activityactive
Protein DomainInterPro | Pfam3D Structure * PDB | PDBe | DrugPort
* ModBase | SwissModel
Structure-based FamilyFamily 1 (CATH: 3.90.190.10)Historical ClassPTPs >> Class I Cys-based PTPs >> VH1-like or dual-specificity phosphatases (DSPs) >> PTENs
Localization cytoplasm; endoplasmic reticulum; golgi apparatus (PubMed: 11716755, 14659893 | Europe PMC)
Catalytic SiteCatalytic Site Atlas Target by Small MoleculesN/A
Gene ExpressionGene Expression Atlas

The Human Protein Atlas

Function and DiseaseOMIM
Protein-protein Interaction Database STRING | IntAct | MINT
Kinase Database Phospho.ELM | PhosphoSite | NetworKIN
Function (UniProt annotation)
N/A
Catalytic Activity (UniProt annotation)
CATALYTIC ACTIVITY: Phosphatidylinositol 3,4,5-trisphosphate + H(2)O = phosphatidylinositol 4,5-bisphosphate + phosphate.
Protein Sequence
MNESPQTNEF KGTTEEAPAK ESPHTSEFKG AALVSPISKS MLERLSKFEV EDAENVASYD SKIKKIVHSI VSSFAFGIFG VFLVLLDVTL LLADLIFTDS KLYIPLEYRS ISLAIGLFFL MDVLLRVFVE GRQQYFSDLF NILDTAIIVI PLLVDVIYIF FDIKLLRNIP RWTHLVRLLR LIILIRIFHL LHQKRQLEKL MRRLVSENKR RYTRDGFDLD LTYVTERIIA MSFPSSGRQS FYRNPIEEVV RFLDKKHRNH YRVYNLCSER AYDPKHFHNR VSRIMIDDHN VPTLHEMVVF TKEVNEWMAQ DLENIVAIHC KGGKGRTGTM VCALLIASEI FLTAEESLYY FGERRTNKTH SNKFQGVETP SQNRYVGYFA QVKHLYNWNL PPRRILFIKR FIIYSIRGDV CDLKVQVVME KKVVFSSTSL GNCSILHDIE TDKILINVYD GPPLYDDVKV QFFSSNLPKY YDNCPFFFWF NTSFIQNNRL CLPRNELDNP HKQKAWKIYP PEFAVEILFG EK
ELM motif
N/A
Gene Ontology
GO:0005789endoplasmic reticulum membrane
GO:0016021integral to membrane
GO:0005216ion channel activity
GO:0016314phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
GO:0004725protein tyrosine phosphatase activity
GO:0008138protein tyrosine/serine/threonine phosphatase activity

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