Top PTPN5
Download FASTA sequences of PTPN5-substrates in Humans
Pathway ID Pathway Name Pathway Description (KEGG) hsa04010 MAPK signaling pathway The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Pathway ID Pathway Name Pathway Description (KEGG) R-HSA-9008059 Interleukin-37 signaling. Interleukins (IL) are immunomodulatory proteins that elicit a wide array of responses in cells and tissues. Interleukin 37 (IL37), also known as IL 1F7, is a member of the IL 1 family (Sharma et al. 2008). Isoform b of IL37 (referred just as IL37) is synthesized as a precursor that requires processing (primarily by caspase 1) to attain full receptor agonist or antagonist function (Kumar et al. 2002). Both full length and processed IL37 can bind to the IL 18 binding protein (IL 18BP) and the Interleukin 18 receptor 1 (IL 18R1) (Shi et al. 2003). Upon binding to the IL18R1, IL37 recruits Single Ig IL 1 related receptor (SIGIRR) (Nold-Petry et al. 2015). The IL37:IL18R1 complex can activate phosphorylation of Signal transducer and activator of transcription 3 (STAT3), Tyrosine protein kinase Mer and Phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase and dual specificity protein phosphatase PTEN and can also inhibit Nuclear factor NF kappa B p105 subunit (NFKB) (Nold-Petry et al. 2015). Processed IL37 can be secreted from the cytosol to the extracellular space or translocated into the nucleus (Bulau et al. 2014). Full length IL37 can also be secreted from the cytosol to the extracellular space (Bulau et al. 2014). Processed IL37 can bind with Mothers against decapentaplegic homolog 3 (SMAD3) in the cytosol and then translocate to the nucleus, where it facilitates transcription of Tyrosine protein phosphatase non receptors (PTPNs) (Nold et al. 2010, Luo et al. 2017). These events ultimately lead to suppression of cytokine production in several types of immune cells resulting in reduced inflammation
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source APOA1 Affinity Capture-MS, anti bait coimmunoprecipitation association, physical 15174051 , (Europe PMC )0.35 BioGRID, IntAct ARL1 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID ATP5PD Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID ATP5PO Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID ATXN7L3B Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID AURKA Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID BZW1 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID CCNQ Two-hybrid physical 21988832 , (Europe PMC )NA BioGRID CUL5 Two-hybrid, two hybrid array physical, physical association 21988832 , (Europe PMC )0.37 BioGRID, IntAct CXCL9 Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 25416956 , (Europe PMC )0.56 BioGRID, IntAct DCAKD Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID DGKE Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID DHCR24 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID DHCR7 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID DLG4 Affinity Capture-Western physical 27457929 , (Europe PMC )NA BioGRID FAF2 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID FYN Affinity Capture-Western physical 11983687 , (Europe PMC )NA BioGRID HLA-A Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID MAPK1 Affinity Capture-MS, Reconstituted Complex, pull down association, physical 27880917 , 28330616 , 9857190 , (Europe PMC )0.35 BioGRID, IntAct MAPK14 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID MAPK1IP1L Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID MAPK3 Affinity Capture-MS, Reconstituted Complex, pull down association, physical 27880917 , 28330616 , 9857190 , (Europe PMC )0.35 BioGRID, IntAct MAPKAPK3 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID MOB1A Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID MOSPD2 Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID MTCH2 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID PRKN Affinity Capture-Western, Biochemical Activity physical 25583483 , (Europe PMC )NA BioGRID PTPN5 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID RPS27A Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID SEC61A1 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID SEC61A2 Affinity Capture-MS, pull down association, physical 27432908 , 28330616 , (Europe PMC )0.35 BioGRID, IntAct SLC27A4 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID SNX4 Two-hybrid, two hybrid array physical, physical association 21988832 , (Europe PMC )0.37 BioGRID, IntAct TBL2 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID TERF1 Two-hybrid, bimolecular fluorescence complementation, pull down physical, physical association 21044950 , (Europe PMC )0.51 BioGRID, IntAct TMEM51 Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 25416956 , (Europe PMC )0.56 BioGRID, IntAct TOMM70 Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID TXNDC5 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID UBC Affinity Capture-Western physical 20427654 , (Europe PMC )NA BioGRID VAPA Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID VAPB Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID VTI1B Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 25416956 , (Europe PMC )0.56 BioGRID, IntAct ZBTB5 Two-hybrid, two hybrid array physical, physical association 21988832 , (Europe PMC )0.37 BioGRID, IntAct
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source ATP5F1 pull down association 28330616 , (Europe PMC )0.35 IntAct ATP5F1B pull down association 28330616 , (Europe PMC )0.35 IntAct ATP5F1C pull down association 28330616 , (Europe PMC )0.35 IntAct ATP5O pull down association 28330616 , (Europe PMC )0.35 IntAct CCNQ two hybrid array physical association 21988832 , (Europe PMC )0.37 IntAct CDKN3 pull down association 28330616 , (Europe PMC )0.35 IntAct CERS2 pull down association 28330616 , (Europe PMC )0.35 IntAct CUL5 Two-hybrid, two hybrid array physical, physical association 21988832 , (Europe PMC )0.37 BioGRID, IntAct CXCL9 Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 25416956 , (Europe PMC )0.56 BioGRID, IntAct DUSP15 pull down association 28330616 , (Europe PMC )0.35 IntAct MAPK1 Affinity Capture-MS, Reconstituted Complex, pull down association, physical 27880917 , 28330616 , 9857190 , (Europe PMC )0.35 BioGRID, IntAct MAPK3 Affinity Capture-MS, Reconstituted Complex, pull down association, physical 27880917 , 28330616 , 9857190 , (Europe PMC )0.35 BioGRID, IntAct POMGNT1 pull down association 28330616 , (Europe PMC )0.35 IntAct PPP2R2D pull down association 28330616 , (Europe PMC )0.35 IntAct RHOT2 pull down association 28330616 , (Europe PMC )0.35 IntAct RPN1 pull down association 28330616 , (Europe PMC )0.35 IntAct RPN2 pull down association 28330616 , (Europe PMC )0.35 IntAct RTN4 pull down association 28330616 , (Europe PMC )0.35 IntAct SEC61A2 Affinity Capture-MS, pull down association, physical 27432908 , 28330616 , (Europe PMC )0.35 BioGRID, IntAct SNX4 Two-hybrid, two hybrid array physical, physical association 21988832 , (Europe PMC )0.37 BioGRID, IntAct TERF1 Two-hybrid, bimolecular fluorescence complementation, pull down physical, physical association 21044950 , (Europe PMC )0.51 BioGRID, IntAct TMEM51 Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 25416956 , (Europe PMC )0.56 BioGRID, IntAct TMEM97 pull down association 28330616 , (Europe PMC )0.35 IntAct VTI1B Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 25416956 , (Europe PMC )0.56 BioGRID, IntAct ZBTB5 Two-hybrid, two hybrid array physical, physical association 21988832 , (Europe PMC )0.37 BioGRID, IntAct
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source APOA1 Affinity Capture-MS, anti bait coimmunoprecipitation association, physical 15174051 , (Europe PMC )0.35 BioGRID, IntAct ARL1 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID ATP5F1 pull down association 28330616 , (Europe PMC )0.35 IntAct ATP5F1B pull down association 28330616 , (Europe PMC )0.35 IntAct ATP5F1C pull down association 28330616 , (Europe PMC )0.35 IntAct ATP5O pull down association 28330616 , (Europe PMC )0.35 IntAct ATP5PD Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID ATP5PO Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID ATXN7L3B Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID AURKA Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID BZW1 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID CCNQ Two-hybrid physical 21988832 , (Europe PMC )NA BioGRID CCNQ two hybrid array physical association 21988832 , (Europe PMC )0.37 IntAct CDKN3 pull down association 28330616 , (Europe PMC )0.35 IntAct CERS2 pull down association 28330616 , (Europe PMC )0.35 IntAct CUL5 Two-hybrid, two hybrid array physical, physical association 21988832 , (Europe PMC )0.37 BioGRID, IntAct CXCL9 Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 25416956 , (Europe PMC )0.56 BioGRID, IntAct DCAKD Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID DGKE Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID DHCR24 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID DHCR7 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID DLG4 Affinity Capture-Western physical 27457929 , (Europe PMC )NA BioGRID DUSP15 pull down association 28330616 , (Europe PMC )0.35 IntAct FAF2 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID FYN Affinity Capture-Western physical 11983687 , (Europe PMC )NA BioGRID HLA-A Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID MAPK1 Affinity Capture-MS, Reconstituted Complex, pull down association, physical 27880917 , 28330616 , 9857190 , (Europe PMC )0.35 BioGRID, IntAct MAPK14 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID MAPK1IP1L Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID MAPK3 Affinity Capture-MS, Reconstituted Complex, pull down association, physical 27880917 , 28330616 , 9857190 , (Europe PMC )0.35 BioGRID, IntAct MAPKAPK3 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID MOB1A Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID MOSPD2 Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID MTCH2 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID POMGNT1 pull down association 28330616 , (Europe PMC )0.35 IntAct PPP2R2D pull down association 28330616 , (Europe PMC )0.35 IntAct PRKN Affinity Capture-Western, Biochemical Activity physical 25583483 , (Europe PMC )NA BioGRID PTPN5 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID RHOT2 pull down association 28330616 , (Europe PMC )0.35 IntAct RPN1 pull down association 28330616 , (Europe PMC )0.35 IntAct RPN2 pull down association 28330616 , (Europe PMC )0.35 IntAct RPS27A Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID RTN4 pull down association 28330616 , (Europe PMC )0.35 IntAct SEC61A1 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID SEC61A2 Affinity Capture-MS, pull down association, physical 27432908 , 28330616 , (Europe PMC )0.35 BioGRID, IntAct SLC27A4 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID SNX4 Two-hybrid, two hybrid array physical, physical association 21988832 , (Europe PMC )0.37 BioGRID, IntAct TBL2 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID TERF1 Two-hybrid, bimolecular fluorescence complementation, pull down physical, physical association 21044950 , (Europe PMC )0.51 BioGRID, IntAct TMEM51 Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 25416956 , (Europe PMC )0.56 BioGRID, IntAct TMEM97 pull down association 28330616 , (Europe PMC )0.35 IntAct TOMM70 Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID TXNDC5 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID UBC Affinity Capture-Western physical 20427654 , (Europe PMC )NA BioGRID VAPA Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID VAPB Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID VTI1B Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 25416956 , (Europe PMC )0.56 BioGRID, IntAct ZBTB5 Two-hybrid, two hybrid array physical, physical association 21988832 , (Europe PMC )0.37 BioGRID, IntAct
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