Top PTPN13
Download FASTA sequences of PTPN13-substrates in Humans
Pathway ID Pathway Name Pathway Description (KEGG) hsa04210 Apoptosis Apoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled by numerous interrelating processes. The 'extrinsic' pathway involves stimulation of members of the tumor necrosis factor (TNF) receptor subfamily, such as TNFRI, CD95/Fas or TRAILR (death receptors), located at the cell surface, by their specific ligands, such as TNF-alpha, FasL or TRAIL, respectively. The 'intrinsic' pathway is activated mainly by non-receptor stimuli, such as DNA damage, ER stress, metabolic stress, UV radiation or growth-factor deprivation. The central event in the 'intrinsic' pathway is the mitochondrial outer membrane permeabilization (MOMP), which leads to the release of cytochrome c. These two pathways converge at the level of effector caspases, such as caspase-3 and caspase-7. The third major pathway is initiated by the constituents of cytotoxic granules (e.g. Perforin and Granzyme B) that are released by CTLs (cytotoxic T-cells) and NK (natural killer) cells. Granzyme B, similarly to the caspases, cleaves its substrates after aspartic acid residues, suggesting that this protease has the ability to activate members of the caspase family directly. It is the balance between the pro-apoptotic and anti-apoptotic signals that eventually determines whether cells will undergo apoptosis, survive or proliferate. TNF family of ligands activates anti-apoptotic or cell-survival signals as well as apoptotic signals. NGF and Interleukin-3 promotes the survival, proliferation and differentiation of neurons or hematopoietic cells, respectively. Withdrawal of these growth factors leads to cell death, as described above.
Pathway ID Pathway Name Pathway Description (KEGG) R-HSA-1660499 Synthesis of PIPs at the plasma membrane. At the plasma membrane, subsequent phosphorylation of phosphatidylinositol 4-phosphate (PI4P) produces phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) and phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) while the actions of various other kinases and phosphatases produces phosphatidylinositol 3-phosphate (PI3P), phosphatidylinositol 5-phosphate (PI5P), phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2), and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) (Zhang et al. 1997, Gurung et al. 2003, Guo et al. 1999, Vanhaesebroeck et al. 1997, Tolias et al. 1998, Schaletzky et al. 2003, Kim et al. 2002, Clarke et al. 2010). Many of the phosphatidylinositol phosphatases that act at the plasma membrane belong to the myotubularin family. Enzymatically inactive myotubularin family members can heterodimerize with catalytically active mytotubularins to regulate their stability, activity and/or substrate specificity (Berger et al. 2006, Zou et al. 2012) R-HSA-9008059 Interleukin-37 signaling. Interleukins (IL) are immunomodulatory proteins that elicit a wide array of responses in cells and tissues. Interleukin 37 (IL37), also known as IL 1F7, is a member of the IL 1 family (Sharma et al. 2008). Isoform b of IL37 (referred just as IL37) is synthesized as a precursor that requires processing (primarily by caspase 1) to attain full receptor agonist or antagonist function (Kumar et al. 2002). Both full length and processed IL37 can bind to the IL 18 binding protein (IL 18BP) and the Interleukin 18 receptor 1 (IL 18R1) (Shi et al. 2003). Upon binding to the IL18R1, IL37 recruits Single Ig IL 1 related receptor (SIGIRR) (Nold-Petry et al. 2015). The IL37:IL18R1 complex can activate phosphorylation of Signal transducer and activator of transcription 3 (STAT3), Tyrosine protein kinase Mer and Phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase and dual specificity protein phosphatase PTEN and can also inhibit Nuclear factor NF kappa B p105 subunit (NFKB) (Nold-Petry et al. 2015). Processed IL37 can be secreted from the cytosol to the extracellular space or translocated into the nucleus (Bulau et al. 2014). Full length IL37 can also be secreted from the cytosol to the extracellular space (Bulau et al. 2014). Processed IL37 can bind with Mothers against decapentaplegic homolog 3 (SMAD3) in the cytosol and then translocate to the nucleus, where it facilitates transcription of Tyrosine protein phosphatase non receptors (PTPNs) (Nold et al. 2010, Luo et al. 2017). These events ultimately lead to suppression of cytokine production in several types of immune cells resulting in reduced inflammation
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source CBY1 Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct CDC25C Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct CGN Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct CTNNB1 Biochemical Activity physical 10951583 , (Europe PMC )NA BioGRID DENND1A Affinity Capture-MS physical 27173435 , (Europe PMC )NA BioGRID DENND4C Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct DFFB Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID DNM2 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID EFNB1 Reconstituted Complex physical 9920925 , (Europe PMC )NA BioGRID EIF4E2 Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct FASLG Reconstituted Complex physical 9261095 , (Europe PMC )NA BioGRID FBXL2 Affinity Capture-Western physical 23604317 , (Europe PMC )NA BioGRID FBXW11 Affinity Capture-MS physical 25515538 , (Europe PMC )NA BioGRID GHR Far Western physical 12907755 , (Europe PMC )NA BioGRID GIGYF1 Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct GIGYF2 Affinity Capture-MS physical 27173435 , (Europe PMC )NA BioGRID HEY1 Affinity Capture-MS physical 27129302 , (Europe PMC )NA BioGRID HNRNPL Affinity Capture-RNA physical 28611215 , (Europe PMC )NA BioGRID INPP5E Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct KCTD3 Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct KIF13B Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct KSR1 Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct LATS1 Proximity Label-MS physical 24255178 , (Europe PMC )NA BioGRID LATS2 Affinity Capture-MS, Proximity Label-MS physical 24255178 , (Europe PMC )NA BioGRID LPIN3 Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct LRFN1 Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct MAST3 Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct MTNR1A Two-hybrid, two hybrid physical, physical association 26514267 , (Europe PMC )0.37 BioGRID, IntAct NF1 Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct NFKBIA Reconstituted Complex, tandem affinity purification physical, physical association 14743216 , 9882613 , (Europe PMC )0.40 BioGRID, IntAct NINL Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct NSD2 Affinity Capture-MS physical 24923560 , (Europe PMC )NA BioGRID PKN2 Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, imaging technique, pull down, two hybrid array colocalization, physical, physical association 11356191 , (Europe PMC )0.60 BioGRID, IntAct, MINT PLEKHA1 Affinity Capture-MS, anti bait coimmunoprecipitation, fluorescence microscopy, pull down colocalization, physical, physical association 14516276 , 27880917 , (Europe PMC )0.56 BioGRID, IntAct, MINT PPM1H Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct PTEN Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID RALGPS2 Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct RAPGEF2 Affinity Capture-MS physical 25332235 , (Europe PMC )NA BioGRID RASSF10 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 24366813 , (Europe PMC )0.35 BioGRID, IntAct RGS2 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID RTKN Affinity Capture-MS physical 27173435 , (Europe PMC )NA BioGRID SH3PXD2A Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct SH3RF3 Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct SIPA1L1 Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct SRGAP2 Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct STXBP4 Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID TANC2 Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct TMEM17 Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct YWHAB Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 24255178 , (Europe PMC )0.35 BioGRID, IntAct ZBTB21 Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source CBY1 Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct CDC25C Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct CGN Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct DENND4C Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct EGLN3 anti tag coimmunoprecipitation association 26972000 , (Europe PMC )0.35 IntAct EIF4E2 Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct EPS15 phosphatase assay dephosphorylation reaction 25728925 , (Europe PMC )0.44 IntAct FAS anti bait coimmunoprecipitation, anti tag coimmunoprecipitation physical association 10918185 , 12724420 , (Europe PMC )0.59 IntAct, MINT GIGYF1 Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct INPP5E Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct KCTD3 Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct KIF13B Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct KSR1 Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct LAMP1 proximity-dependent biotin identification association 29568061 , (Europe PMC )0.35 IntAct LATS1 proximity-dependent biotin identification colocalization 24255178 , (Europe PMC )0.35 IntAct LPIN3 Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct LRFN1 Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct LRFN4 anti tag coimmunoprecipitation association 22677168 , (Europe PMC )0.35 IntAct, MINT MAST3 Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct MTNR1A Two-hybrid, two hybrid physical, physical association 26514267 , (Europe PMC )0.37 BioGRID, IntAct NEURL4 anti tag coimmunoprecipitation association 29426014 , (Europe PMC )0.35 IntAct NF1 Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct NFKBIA Reconstituted Complex, tandem affinity purification physical, physical association 14743216 , 9882613 , (Europe PMC )0.40 BioGRID, IntAct NINL Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct PDCD10 anti tag coimmunoprecipitation, phosphatase assay, pull down, two hybrid association, dephosphorylation reaction, physical association 17657516 , (Europe PMC )0.44, 0.55 IntAct PDLIM4 fluorescence technology colocalization 10826496 , (Europe PMC )0.35 IntAct, MINT PKN2 Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, imaging technique, pull down, two hybrid array colocalization, physical, physical association 11356191 , (Europe PMC )0.60 BioGRID, IntAct, MINT PLEKHA1 Affinity Capture-MS, anti bait coimmunoprecipitation, fluorescence microscopy, pull down colocalization, physical, physical association 14516276 , 27880917 , (Europe PMC )0.56 BioGRID, IntAct, MINT PLEKHA2 pull down physical association 14516276 , (Europe PMC )0.40 IntAct, MINT PPM1H Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct RALGPS2 Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct RAPGEF6 biophysical, isothermal titration calorimetry, nuclear magnetic resonance, x-ray crystallography association, direct interaction 12095257 , 14698303 , 17240990 , (Europe PMC )0.76 IntAct, MINT RASSF10 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 24366813 , (Europe PMC )0.35 BioGRID, IntAct SH3PXD2A Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct SH3RF3 Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct SIPA1L1 Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct SQSTM1 anti bait coimmunoprecipitation physical association 24316673 , (Europe PMC )0.40 IntAct SRGAP2 Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct STK25 phosphatase assay dephosphorylation reaction 17657516 , (Europe PMC )0.44 IntAct TANC2 Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct TMEM17 Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct TUBA1A pull down association 27291054 , (Europe PMC )0.35 IntAct TUBB3 pull down association 27291054 , (Europe PMC )0.35 IntAct YWHAB Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 24255178 , (Europe PMC )0.35 BioGRID, IntAct ZBTB21 Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source FAS anti bait coimmunoprecipitation, anti tag coimmunoprecipitation physical association 10918185 , 12724420 , (Europe PMC )0.59 IntAct, MINT LRFN4 anti tag coimmunoprecipitation association 22677168 , (Europe PMC )0.35 IntAct, MINT PDLIM4 fluorescence technology colocalization 10826496 , (Europe PMC )0.35 IntAct, MINT PKN2 Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, imaging technique, pull down, two hybrid array colocalization, physical, physical association 11356191 , (Europe PMC )0.60 BioGRID, IntAct, MINT PLEKHA1 Affinity Capture-MS, anti bait coimmunoprecipitation, fluorescence microscopy, pull down colocalization, physical, physical association 14516276 , 27880917 , (Europe PMC )0.56 BioGRID, IntAct, MINT PLEKHA2 pull down physical association 14516276 , (Europe PMC )0.40 IntAct, MINT RAPGEF6 biophysical, isothermal titration calorimetry, nuclear magnetic resonance, x-ray crystallography association, direct interaction 12095257 , 14698303 , 17240990 , (Europe PMC )0.76 IntAct, MINT
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source ARHGAP29 Reconstituted Complex physical 9305890 , (Europe PMC )NA BioGRID CBY1 Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct CDC25C Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct CGN Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct CTNNB1 Biochemical Activity physical 10951583 , (Europe PMC )NA BioGRID DENND1A Affinity Capture-MS physical 27173435 , (Europe PMC )NA BioGRID DENND4C Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct DFFB Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID DNM2 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID EFNB1 Reconstituted Complex physical 9920925 , (Europe PMC )NA BioGRID EGLN3 anti tag coimmunoprecipitation association 26972000 , (Europe PMC )0.35 IntAct EIF4E2 Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct EPS15 phosphatase assay dephosphorylation reaction 25728925 , (Europe PMC )0.44 IntAct FAS anti bait coimmunoprecipitation, anti tag coimmunoprecipitation physical association 10918185 , 12724420 , (Europe PMC )0.59 IntAct, MINT FASLG Reconstituted Complex physical 9261095 , (Europe PMC )NA BioGRID FBXL2 Affinity Capture-Western physical 23604317 , (Europe PMC )NA BioGRID FBXW11 Affinity Capture-MS physical 25515538 , (Europe PMC )NA BioGRID GHR Far Western physical 12907755 , (Europe PMC )NA BioGRID GIGYF1 Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct GIGYF2 Affinity Capture-MS physical 27173435 , (Europe PMC )NA BioGRID HEY1 Affinity Capture-MS physical 27129302 , (Europe PMC )NA BioGRID HNRNPL Affinity Capture-RNA physical 28611215 , (Europe PMC )NA BioGRID INPP5E Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct KCTD3 Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct KIF13B Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct KSR1 Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct LAMP1 proximity-dependent biotin identification association 29568061 , (Europe PMC )0.35 IntAct LATS1 Proximity Label-MS physical 24255178 , (Europe PMC )NA BioGRID LATS1 proximity-dependent biotin identification colocalization 24255178 , (Europe PMC )0.35 IntAct LATS2 Affinity Capture-MS, Proximity Label-MS physical 24255178 , (Europe PMC )NA BioGRID LPIN3 Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct LRFN1 Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct LRFN4 anti tag coimmunoprecipitation association 22677168 , (Europe PMC )0.35 IntAct, MINT MAST3 Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct MTNR1A Two-hybrid, two hybrid physical, physical association 26514267 , (Europe PMC )0.37 BioGRID, IntAct NEURL4 anti tag coimmunoprecipitation association 29426014 , (Europe PMC )0.35 IntAct NF1 Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct NFKBIA Reconstituted Complex, tandem affinity purification physical, physical association 14743216 , 9882613 , (Europe PMC )0.40 BioGRID, IntAct NINL Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct NSD2 Affinity Capture-MS physical 24923560 , (Europe PMC )NA BioGRID PDCD10 anti tag coimmunoprecipitation, phosphatase assay, pull down, two hybrid association, dephosphorylation reaction, physical association 17657516 , (Europe PMC )0.44, 0.55 IntAct PDLIM4 fluorescence technology colocalization 10826496 , (Europe PMC )0.35 IntAct, MINT PKN2 Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, imaging technique, pull down, two hybrid array colocalization, physical, physical association 11356191 , (Europe PMC )0.60 BioGRID, IntAct, MINT PLEKHA1 Affinity Capture-MS, anti bait coimmunoprecipitation, fluorescence microscopy, pull down colocalization, physical, physical association 14516276 , 27880917 , (Europe PMC )0.56 BioGRID, IntAct, MINT PLEKHA2 pull down physical association 14516276 , (Europe PMC )0.40 IntAct, MINT PPM1H Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct PTEN Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID RALGPS2 Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct RAPGEF2 Affinity Capture-MS physical 25332235 , (Europe PMC )NA BioGRID RAPGEF6 biophysical, isothermal titration calorimetry, nuclear magnetic resonance, x-ray crystallography association, direct interaction 12095257 , 14698303 , 17240990 , (Europe PMC )0.76 IntAct, MINT RASSF10 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 24366813 , (Europe PMC )0.35 BioGRID, IntAct RGS2 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID RTKN Affinity Capture-MS physical 27173435 , (Europe PMC )NA BioGRID SH3PXD2A Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct SH3RF3 Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct SIPA1L1 Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct SQSTM1 anti bait coimmunoprecipitation physical association 24316673 , (Europe PMC )0.40 IntAct SRGAP2 Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct STK25 phosphatase assay dephosphorylation reaction 17657516 , (Europe PMC )0.44 IntAct STXBP4 Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID TANC2 Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct TMEM17 Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct TUBA1A pull down association 27291054 , (Europe PMC )0.35 IntAct TUBB3 pull down association 27291054 , (Europe PMC )0.35 IntAct YWHAB Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 24255178 , (Europe PMC )0.35 BioGRID, IntAct ZBTB21 Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435 , Europe PMC )0.27 BioGRID, IntAct
Phosphorylating Kinases Phosphoresidues Detection Method PubMed IDs Source
Visualize a network of protein kinases and phosphatases phosphorylating and dephosphorylating this protein respectively
Unknown S1067_HSSGNSSsQVPLKEN , S1082_DVLHKRWsIVSSPER , S1086_KRWSIVSsPEREITL , S1323_SDRGDSDsDEATYSS , S1438_HKQAVETsRNTGQVV , S1495_VKDYSFVsEENTFEV , S1514_NSSGLGFsFSREDNL , S1519_GFSFSREsNLIPEQI , S1610_PLQSPAQsLPNSSKD , S1629_SCVEQSTsSDENEMS , S1634_STSSDENsMSDKSKK , S2192_KVLPSGKsTGANLKS , S2202_ANLKSVIsVLRGLLD , S2364_LEDIQTRsVRHISHL , S2374_HISHLNFsAWPDHDT , S2383_WPDHDTPsQPDDLLT , S2388_TPSQPDDsLTFISYM , S2393_DDLLTFIsYMRHIHR , S2398_FISYMRHsHRSGPII , S890_IERASFRsLNLQAES , S895_FRSLNLQsESVRGFN , S908_FNMGRAIsTGSLASS , S911_GRAISTGsLASSTLN , Y2203_NLKSVIRyLRGLLDQ , Y2375_ISHLNFTyWPDHDTP , Y2394_DLLTFISyMRHIHRS , Y2399_ISYMRHIyRSGPIIT , HTP, in vivo 18220336 , 18452278 , 19413330 , 19664994 , 19664995 ,(Europe PMC )HPRD, PhosphoELM ,
Statistics
