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Collapse Statistics
226 human active and 11 inactive phosphatases in total;
194 phosphatases have substrate data;
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305 protein substrates;
89 non-protein substrates;
1114 dephosphorylation interactions;
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213 KEGG pathways;
206 NCI Nature PID pathways
560 Reactome pathways;
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last update: 18 Feb, 2016

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PPP1CA

Gene Name PPP1CA (QuickGO)
Structure of phosphatase catalytic domain

PDB ID: 3E7A
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SynonymsPPP1CA PPP1A
Protein NameSerine/threonine-protein phosphatase PP1-alpha catalytic subunit
Alternative Name(s)
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16)
Ensembl Gene IDENSG00000172531
EntrezGene ID5499
UniProt AC (Human)P62136 (protein sequence)
Enzyme ClassEC 3.1.3.16 (BRENDA )
Molecular Weight37512
Protein Length330
Phosphatase activityactive
Protein DomainInterPro | Pfam3D Structure * PDB | PDBe | DrugPort
* ModBase | SwissModel
Structure-based FamilyFamily 5 (CATH: 3.60.21.10)Historical ClassPSTPs >> PPP >> PP1
Localization cytoplasm; cytoskeleton; nucleus (PubMed: 11739654, 17965019, 2161401, 11790298, 15635413, 9282913 | Europe PMC)
Catalytic SiteCatalytic Site Atlas Target by Small MoleculesChEMBL
Gene ExpressionGene Expression Atlas

The Human Protein Atlas

Function and DiseaseOMIM
Protein-protein Interaction Database STRING | IntAct | MINT
Kinase Database Phospho.ELM | PhosphoSite | NetworKIN
Function (UniProt annotation)
FUNCTION: Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage.
Catalytic Activity (UniProt annotation)
CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein + phosphate.
Protein Sequence
MSDSEKLNLD SIIGRLLEVQ GSRPGKNVQL TENEIRGLCL KSREIFLSQP ILLELEAPLK ICGDIHGQYY DLLRLFEYGG FPPESNYLFL GDYVDRGKQS LETICLLLAY KIKYPENFFL LRGNHECASI NRIYGFYDEC KRRYNIKLWK TFTDCFNCLP IAAIVDEKIF CCHGGLSPDL QSMEQIRRIM RPTDVPDQGL LCDLLWSDPD KDVQGWGEND RGVSFTFGAE VVAKFLHKHD LDLICRAHQV VEDGYEFFAK RQLVTLFSAP NYCGEFDNAG AMMSVDETLM CSFQILKPAD KNKGKYGQFS GLNPGGRPIT PPRNSAKAKK
ELM motif
N/A
Gene Ontology
GO:0070688MLL5-L complex
GO:0072357PTW/PP1 phosphatase complex
GO:0007049cell cycle
GO:0051301cell division
GO:0005829cytosol
GO:0005977glycogen metabolic process
GO:0046872metal ion binding
GO:0005730nucleolus
GO:0005515protein binding
GO:0006470protein dephosphorylation
GO:0008599protein phosphatase type 1 regulator activity
GO:0004722protein serine/threonine phosphatase activity
GO:0019433triglyceride catabolic process

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