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Collapse Statistics
226 human active and 11 inactive phosphatases in total;
194 phosphatases have substrate data;
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305 protein substrates;
89 non-protein substrates;
1114 dephosphorylation interactions;
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213 KEGG pathways;
206 NCI Nature PID pathways
560 Reactome pathways;
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last update: 18 Feb, 2016

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PPM1A

Gene Name PPM1A (QuickGO)
Structure of phosphatase catalytic domain

PDB ID: 3FXK
(LeftMouse - Rotate; Shift+Left - Scale; Ctrl+Left - Translate)
SynonymsPPM1A PPPM1A
Protein NameProtein phosphatase 1A
Alternative Name(s)
Protein phosphatase 1A (EC 3.1.3.16) (Protein phosphatase 2C isoform alpha) (PP2C-alpha) (Protein phosphatase IA)
Ensembl Gene IDENSG00000100614
EntrezGene ID5494
UniProt AC (Human)P35813 (protein sequence)
Enzyme ClassEC 3.1.3.16 (BRENDA )
Molecular Weight42448
Protein Length382
Phosphatase activityactive
Protein DomainInterPro | Pfam3D Structure * PDB | PDBe | DrugPort
* ModBase | SwissModel
Structure-based FamilyFamily 6 (CATH: 3.60.40.10)Historical ClassPSTPs >> PPM >> PP2C
Localization cytoplasm; nucleus (PubMed: 9003755, 11479720 | Europe PMC)
Catalytic SiteCatalytic Site Atlas Target by Small MoleculesChEMBL
Gene ExpressionGene Expression Atlas

The Human Protein Atlas

Function and DiseaseOMIM
Protein-protein Interaction Database STRING | IntAct | MINT
Kinase Database Phospho.ELM | PhosphoSite | NetworKIN
Function (UniProt annotation)
FUNCTION: Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling.
Catalytic Activity (UniProt annotation)
CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein + phosphate.
Protein Sequence
MGAFLDKPKM EKHNAQGQGN GLRYGLSSMQ GWRVEMEDAH TAVIGLPSGL ESWSFFAVYD GHAGSQVAKY CCEHLLDHIT NNQDFKGSAG APSVENVKNG IRTGFLEIDE HMRVMSEKKH GADRSGSTAV GVLISPQHTY FINCGDSRGL LCRNRKVHFF TQDHKPSNPL EKERIQNAGG SVMIQRVNGS LAVSRALGDF DYKCVHGKGP TEQLVSPEPE VHDIERSEED DQFIILACDG IWDVMGNEEL CDFVRSRLEV TDDLEKVCNE VVDTCLYKGS RDNMSVILIC FPNAPKVSPE AVKKEAELDK YLECRVEEII KKQGEGVPDL VHVMRTLASE NIPSLPPGGE LASKRNVIEA VYNRLNPYKN DDTDSTSTDD MW
ELM motif
N/A
Gene Ontology
GO:0016055Wnt receptor signaling pathway
GO:0007050cell cycle arrest
GO:0005829cytosol
GO:0008286insulin receptor signaling pathway
GO:0000287magnesium ion binding
GO:0030145manganese ion binding
GO:0005634nucleus
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0030177positive regulation of Wnt receptor signaling pathway
GO:0045893positive regulation of transcription, DNA-dependent
GO:0006470protein dephosphorylation
GO:0004722protein serine/threonine phosphatase activity
GO:0008287protein serine/threonine phosphatase complex
GO:0004871signal transducer activity

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