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Collapse Statistics
226 human active and 11 inactive phosphatases in total;
194 phosphatases have substrate data;
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305 protein substrates;
89 non-protein substrates;
1114 dephosphorylation interactions;
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213 KEGG pathways;
206 NCI Nature PID pathways
560 Reactome pathways;
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last update: 18 Feb, 2016

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PPAP2C

Gene Name PPAP2C (QuickGO)SynonymsPPAP2C LPP2
Protein NameLipid phosphate phosphohydrolase 2
Alternative name(s)
Lipid phosphate phosphohydrolase 2 (EC 3.1.3.4) (PAP2-gamma) (PAP2-G) (Phosphatidate phosphohydrolase type 2c) (Phosphatidic acid phosphatase 2c) (PAP-2c) (PAP2c)
Ensembl Gene IDENSG00000141934EntrezGene ID8612
UniProt AC (Human)O43688 (protein sequence)Enzyme ClassEC 3.1.3.4 (BRENDA )
Molecular Weight32574Protein Length288
Phosphatase activityactive
Protein DomainInterPro | Pfam3D Structure * PDB | PDBe | DrugPort
* ModBase | SwissModel
Structure-based FamilyFamily 12 (CATH: 1.20.144.10)Historical ClassPhosphatidic acid phosphatase (PAP)
Localization cytosol; plasma membrane; vesicle (PubMed: 9705349, 15960610 | Europe PMC)
Catalytic SiteCatalytic Site Atlas Target by Small MoleculesN/A
Gene ExpressionGene Expression Atlas

The Human Protein Atlas

Function and DiseaseOMIM
Protein-protein Interaction Database STRING | IntAct | MINT
Kinase Database Phospho.ELM | PhosphoSite | NetworKIN
Function (UniProt annotation)
FUNCTION: Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is PA > C-1-P > LPA > S-1-P.
Catalytic Activity (UniProt annotation)
CATALYTIC ACTIVITY: A 1,2-diacylglycerol 3-phosphate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate.
Protein Sequence
MQRRWVFVLL DVLCLLVASL PFAILTLVNA PYKRGFYCGD DSIRYPYRPD TITHGLMAGV TITATVILVS AGEAYLVYTD RLYSRSDFNN YVAAVYKVLG TFLFGAAVSQ SLTDLAKYMI GRLRPNFLAV CDPDWSRVNC SVYVQLEKVC RGNPADVTEA RLSFYSGHSS FGMYCMVFLA LYVQARLCWK WARLLRPTVQ FFLVAFALYV GYTRVSDYKH HWSDVLVGLL QGALVAALTV CYISDFFKAR PPQHCLKEEE LERKPSLSLT LTLGEADHNH YGYPHSSS
ELM motif
N/A
Gene Ontology
GO:0016021integral to membrane
GO:0008195phosphatidate phosphatase activity
GO:0004721phosphoprotein phosphatase activity
GO:0005886plasma membrane
GO:0006665sphingolipid metabolic process
GO:0042392sphingosine-1-phosphate phosphatase activity

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