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Collapse Statistics
226 human active and 11 inactive phosphatases in total;
194 phosphatases have substrate data;
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305 protein substrates;
89 non-protein substrates;
1114 dephosphorylation interactions;
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213 KEGG pathways;
206 NCI Nature PID pathways
560 Reactome pathways;
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last update: 18 Feb, 2016

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PPAP2B

Gene Name PPAP2B (QuickGO)SynonymsPPAP2B LPP3
Protein NameLipid phosphate phosphohydrolase 3
Alternative name(s)
Lipid phosphate phosphohydrolase 3 (EC 3.1.3.4) (PAP2-beta) (Phosphatidate phosphohydrolase type 2b) (Phosphatidic acid phosphatase 2b) (PAP-2b) (PAP2b) (Vascular endothelial growth factor and type I collagen-inducible protein) (VCIP)
Ensembl Gene IDENSG00000162407EntrezGene ID8613
UniProt AC (Human)O14495 (protein sequence)Enzyme ClassEC 3.1.3.4 (BRENDA )
Molecular Weight35116Protein Length311
Phosphatase activityactive
Protein DomainInterPro | Pfam3D Structure * PDB | PDBe | DrugPort
* ModBase | SwissModel
Structure-based FamilyFamily 12 (CATH: 1.20.144.10)Historical ClassPhosphatidic acid phosphatase (PAP)
Localization cytosol; plasma membrane (PubMed: 9705349, 10564277 | Europe PMC)
Catalytic SiteCatalytic Site Atlas Target by Small MoleculesN/A
Gene ExpressionGene Expression Atlas

The Human Protein Atlas

Function and DiseaseOMIM
Protein-protein Interaction Database STRING | IntAct | MINT
Kinase Database Phospho.ELM | PhosphoSite | NetworKIN
Function (UniProt annotation)
FUNCTION: Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA = PA > C-1-P > S-1-P. May be involved in cell adhesion and in cell-cell interactions.
Catalytic Activity (UniProt annotation)
CATALYTIC ACTIVITY: A 1,2-diacylglycerol 3-phosphate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate.
Protein Sequence
MQNYKYDKAI VPESKNGGSP ALNNNPRRSG SKRVLLICLD LFCLFMAGLP FLIIETSTIK PYHRGFYCND ESIKYPLKTG ETINDAVLCA VGIVIAILAI ITGEFYRIYY LKKSRSTIQN PYVAALYKQV GCFLFGCAIS QSFTDIAKVS IGRLRPHFLS VCNPDFSQIN CSEGYIQNYR CRGDDSKVQE ARKSFFSGHA SFSMYTMLYL VLYLQARFTW RGARLLRPLL QFTLIMMAFY TGLSRVSDHK HHPSDVLAGF AQGALVACCI VFFVSDLFKT KTTLSLPAPA IRKEILSPVD IIDRNNHHNM M
ELM motif
N/A
Gene Ontology
GO:0005794Golgi apparatus
GO:0005912adherens junction
GO:0044329canonical Wnt receptor signaling pathway involved in positive regulation of cell-cell adhesion
GO:0044328canonical Wnt receptor signaling pathway involved in positive regulation of endothelial cell migration
GO:0044330canonical Wnt receptor signaling pathway involved in positive regulation of wound healing
GO:0008354germ cell migration
GO:0034109homotypic cell-cell adhesion
GO:0016021integral to membrane
GO:0001933negative regulation of protein phosphorylation
GO:0008195phosphatidate phosphatase activity
GO:0004721phosphoprotein phosphatase activity
GO:0051091positive regulation of sequence-specific DNA binding transcription factor activity
GO:0005515protein binding
GO:0050821protein stabilization
GO:0006665sphingolipid metabolic process
GO:0042392sphingosine-1-phosphate phosphatase activity

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