spacer
Collapse Statistics
226 human active and 11 inactive phosphatases in total;
194 phosphatases have substrate data;
--------------------------------
305 protein substrates;
89 non-protein substrates;
1114 dephosphorylation interactions;
--------------------------------
213 KEGG pathways;
206 NCI Nature PID pathways
560 Reactome pathways;
--------------------------------
last update: 18 Feb, 2016

spacer

PMM1

Gene Name PMM1 (QuickGO)
Structure of phosphatase catalytic domain

PDB ID: 2FUE
(LeftMouse - Rotate; Shift+Left - Scale; Ctrl+Left - Translate)
SynonymsPMM1 PMMH22
Protein NamePhosphomannomutase 1 (PMM 1)
Alternative Name(s)
Phosphomannomutase 1 (PMM 1) (EC 5.4.2.8) (PMMH-22)
Ensembl Gene IDENSG00000100417
EntrezGene ID5372
UniProt AC (Human)Q92871 (protein sequence)
Enzyme ClassEC 5.4.2.8 (BRENDA )
Molecular Weight29747
Protein Length262
Phosphatase activitydeprecated
Protein DomainInterPro | Pfam3D Structure * PDB | PDBe | DrugPort
* ModBase | SwissModel
Structure-based FamilyFamily 7 (CATH: 3.40.50.1000)Historical Classeukaryotic PMM family
Localization cytoplasm (PubMed: 9376685 | Europe PMC)
Catalytic SiteCatalytic Site Atlas Target by Small MoleculesN/A
Gene ExpressionGene Expression Atlas

The Human Protein Atlas

Function and DiseaseOMIM
Protein-protein Interaction Database STRING | IntAct | MINT
Kinase Database Phospho.ELM | PhosphoSite | NetworKIN
Function (UniProt annotation)
FUNCTION: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. In addition, may be responsible for the degradation of glucose-1,6-bisphosphate in ischemic brain.
Catalytic Activity (UniProt annotation)
CATALYTIC ACTIVITY: Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.
Protein Sequence
MAVTAQAARR KERVLCLFDV DGTLTPARQK IDPEVAAFLQ KLRSRVQIGV VGGSDYCKIA EQLGDGDEVI EKFDYVFAEN GTVQYKHGRL LSKQTIQNHL GEELLQDLIN FCLSYMALLR LPKKRGTFIE FRNGMLNISP IGRSCTLEER IEFSELDKKE KIREKFVEAL KTEFAGKGLR FSRGGMISFD VFPEGWDKRY CLDSLDQDSF DTIHFFGNET SPGGNDFEIF ADPRTVGHSV VSPQDTVQRC REIFFPETAH EA
ELM motif
N/A
Gene Ontology
GO:0009298GDP-mannose biosynthetic process
GO:0005829cytosol
GO:0006488dolichol-linked oligosaccharide biosynthetic process
GO:0046872metal ion binding
GO:0043025neuronal cell body
GO:0004615phosphomannomutase activity
GO:0043687post-translational protein modification
GO:0018279protein N-linked glycosylation via asparagine

spacer
spacer