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Collapse Statistics
226 human active and 11 inactive phosphatases in total;
194 phosphatases have substrate data;
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305 protein substrates;
89 non-protein substrates;
1114 dephosphorylation interactions;
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213 KEGG pathways;
206 NCI Nature PID pathways
560 Reactome pathways;
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last update: 18 Feb, 2016

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PGAM4

Gene Name PGAM4 (QuickGO)SynonymsPGAM4 PGAM3
Protein NameProbable phosphoglycerate mutase 4
Alternative name(s)
Probable phosphoglycerate mutase 4 (EC 3.1.3.13) (EC 5.4.2.1) (EC 5.4.2.4)
Ensembl Gene IDENSG00000226784EntrezGene ID441531
UniProt AC (Human)Q8N0Y7 (protein sequence)Enzyme ClassEC 3.1.3.13, 5.4.2.1, 5.4.2.4 (BRENDA )
Molecular Weight28777Protein Length254
Phosphatase activityactive
Protein DomainInterPro | Pfam3D Structure * PDB | PDBe | DrugPort
* ModBase | SwissModel
Structure-based FamilyFamily 8 (CATH: 3.40.50.1240)Historical ClassPhosphoglycerate mutase
Localization N/A
Catalytic SiteCatalytic Site Atlas Target by Small MoleculesN/A
Gene ExpressionGene Expression Atlas

The Human Protein Atlas

Function and DiseaseOMIM
Protein-protein Interaction Database STRING | IntAct | MINT
Kinase Database Phospho.ELM | PhosphoSite | NetworKIN
Function (UniProt annotation)
N/A
Catalytic Activity (UniProt annotation)
CATALYTIC ACTIVITY: 2-phospho-D-glycerate = 3-phospho-D-glycerate.; CATALYTIC ACTIVITY: 3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate.; CATALYTIC ACTIVITY: 2,3-bisphospho-D-glycerate + H(2)O = 3-phospho-D-glycerate + phosphate.
Protein Sequence
MAAYKLVLIR HGESTWNLEN RFSCWYDADL SPAGHEEAKR GGQALRDAGY EFDICLTSVQ KRVIRTLWTV LDAIDQMWLP VVRTWRLNER HYGGLTGLNK AETAAKHGEA QVKIWRRSYD VPPPPMEPDH PFYSNISKDR RYADLTEDQL PSYESPKDTI ARALPFWNEE IVPQIKEGKR VLIAAHGNSL QGIAKHVEGL SEEAIMELNL PTGIPIVYEL DKNLKPIKPM QFLGDEETVC KAIEAVAAQG KAKK
ELM motif
N/A
Gene Ontology
GO:0004083bisphosphoglycerate 2-phosphatase activity
GO:0004082bisphosphoglycerate mutase activity
GO:0006096glycolysis
GO:0004619phosphoglycerate mutase activity

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