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Collapse Statistics
226 human active and 11 inactive phosphatases in total;
194 phosphatases have substrate data;
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305 protein substrates;
89 non-protein substrates;
1114 dephosphorylation interactions;
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213 KEGG pathways;
206 NCI Nature PID pathways
560 Reactome pathways;
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last update: 18 Feb, 2016

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PGAM2

Gene Name PGAM2 (QuickGO)SynonymsPGAM2 PGAMM
Protein NamePhosphoglycerate mutase 2
Alternative name(s)
Phosphoglycerate mutase 2 (EC 3.1.3.13) (EC 5.4.2.1) (EC 5.4.2.4) (BPG-dependent PGAM 2) (Muscle-specific phosphoglycerate mutase) (Phosphoglycerate mutase isozyme M) (PGAM-M)
Ensembl Gene IDENSG00000164708EntrezGene ID5224
UniProt AC (Human)P15259 (protein sequence)Enzyme ClassEC 3.1.3.13, 5.4.2.1, 5.4.2.4 (BRENDA )
Molecular Weight28766Protein Length253
Phosphatase activityactive
Protein DomainInterPro | Pfam3D Structure * PDB | PDBe | DrugPort
* ModBase | SwissModel
Structure-based FamilyFamily 8 (CATH: 3.40.50.1240)Historical ClassPhosphoglycerate mutase
Localization cytoplasm (PubMed: 2822696 | Europe PMC)
Catalytic SiteCatalytic Site Atlas Target by Small MoleculesN/A
Gene ExpressionGene Expression Atlas

The Human Protein Atlas

Function and DiseaseOMIM
Protein-protein Interaction Database STRING | IntAct | MINT
Kinase Database Phospho.ELM | PhosphoSite | NetworKIN
Function (UniProt annotation)
FUNCTION: Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase) and EC 3.1.3.13 (phosphatase), but with a reduced activity.
Catalytic Activity (UniProt annotation)
CATALYTIC ACTIVITY: 2-phospho-D-glycerate = 3-phospho-D-glycerate.; CATALYTIC ACTIVITY: 3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate.; CATALYTIC ACTIVITY: 2,3-bisphospho-D-glycerate + H(2)O = 3-phospho-D-glycerate + phosphate.
Protein Sequence
MATHRLVMVR HGESTWNQEN RFCGWFDAEL SEKGTEEAKR GAKAIKDAKM EFDICYTSVL KRAIRTLWAI LDGTDQMWLP VVRTWRLNER HYGGLTGLNK AETAAKHGEE QVKIWRRSFD IPPPPMDEKH PYYNSISKER RYAGLKPGEL PTCESLKDTI ARALPFWNEE IVPQIKAGKR VLIAAHGNSL RGIVKHLEGM SDQAIMELNL PTGIPIVYEL NKELKPTKPM QFLGDEETVR KAMEAVAAQG KAK
ELM motif
N/A
Gene Ontology
GO:0004083bisphosphoglycerate 2-phosphatase activity
GO:0004082bisphosphoglycerate mutase activity
GO:0005829cytosol
GO:0006094gluconeogenesis
GO:0006096glycolysis
GO:0006941striated muscle contraction

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