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Collapse Statistics
226 human active and 11 inactive phosphatases in total;
194 phosphatases have substrate data;
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305 protein substrates;
89 non-protein substrates;
1114 dephosphorylation interactions;
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213 KEGG pathways;
206 NCI Nature PID pathways
560 Reactome pathways;
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last update: 18 Feb, 2016

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PGAM1

Gene Name PGAM1 (QuickGO)
Structure of phosphatase catalytic domain

PDB ID: 1YFK
(LeftMouse - Rotate; Shift+Left - Scale; Ctrl+Left - Translate)
SynonymsPGAM1 PGAMA CDABP0006
Protein NamePhosphoglycerate mutase 1
Alternative Name(s)
Phosphoglycerate mutase 1 (EC 3.1.3.13) (EC 5.4.2.1) (EC 5.4.2.4) (BPG-dependent PGAM 1) (Phosphoglycerate mutase isozyme B) (PGAM-B) (PGAM-1)
Ensembl Gene IDENSG00000171314
EntrezGene ID5223
UniProt AC (Human)P18669 (protein sequence)
Enzyme ClassEC 3.1.3.13, 5.4.2.1, 5.4.2.4 (BRENDA )
Molecular Weight28804
Protein Length254
Phosphatase activityactive
Protein DomainInterPro | Pfam3D Structure * PDB | PDBe | DrugPort
* ModBase | SwissModel
Structure-based FamilyFamily 8 (CATH: 3.40.50.1240)Historical ClassPhosphoglycerate mutase
Localization cytoplasm (PubMed: 2822696 | Europe PMC)
Catalytic SiteCatalytic Site Atlas Target by Small MoleculesN/A
Gene ExpressionGene Expression Atlas

The Human Protein Atlas

Function and DiseaseOMIM
Protein-protein Interaction Database STRING | IntAct | MINT
Kinase Database Phospho.ELM | PhosphoSite | NetworKIN
Function (UniProt annotation)
FUNCTION: Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase) and EC 3.1.3.13 (phosphatase), but with a reduced activity.
Catalytic Activity (UniProt annotation)
CATALYTIC ACTIVITY: 2-phospho-D-glycerate = 3-phospho-D-glycerate.; CATALYTIC ACTIVITY: 3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate.; CATALYTIC ACTIVITY: 2,3-bisphospho-D-glycerate + H(2)O = 3-phospho-D-glycerate + phosphate.
Protein Sequence
MAAYKLVLIR HGESAWNLEN RFSGWYDADL SPAGHEEAKR GGQALRDAGY EFDICFTSVQ KRAIRTLWTV LDAIDQMWLP VVRTWRLNER HYGGLTGLNK AETAAKHGEA QVKIWRRSYD VPPPPMEPDH PFYSNISKDR RYADLTEDQL PSCESLKDTI ARALPFWNEE IVPQIKEGKR VLIAAHGNSL RGIVKHLEGL SEEAIMELNL PTGIPIVYEL DKNLKPIKPM QFLGDEETVR KAMEAVAAQG KAKK
ELM motif
N/A
Gene Ontology
GO:0004083bisphosphoglycerate 2-phosphatase activity
GO:0004082bisphosphoglycerate mutase activity
GO:0005829cytosol
GO:0006094gluconeogenesis
GO:0006096glycolysis
GO:0004619phosphoglycerate mutase activity
GO:0019901protein kinase binding
GO:0006110regulation of glycolysis
GO:0043456regulation of pentose-phosphate shunt
GO:0045730respiratory burst

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