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Collapse Statistics
226 human active and 11 inactive phosphatases in total;
194 phosphatases have substrate data;
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305 protein substrates;
89 non-protein substrates;
1114 dephosphorylation interactions;
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213 KEGG pathways;
206 NCI Nature PID pathways
560 Reactome pathways;
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last update: 18 Feb, 2016

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NT5M

Gene Name NT5M (QuickGO)
Structure of phosphatase catalytic domain

PDB ID: 1Q92
(LeftMouse - Rotate; Shift+Left - Scale; Ctrl+Left - Translate)
SynonymsNT5M DNT2
Protein Name5'(3')-deoxyribonucleotidase, mitochondrial
Alternative Name(s)
5'(3')-deoxyribonucleotidase, mitochondrial (5',3'-nucleotidase, mitochondrial) (EC 3.1.3.-) (Deoxy-5'-nucleotidase 2) (dNT-2)
Ensembl Gene IDENSG00000205309
EntrezGene ID56953
UniProt AC (Human)Q9NPB1 (protein sequence)
Enzyme ClassEC 3.1.3.- (BRENDA )
Molecular Weight25862
Protein Length228
Phosphatase activityactive
Protein DomainInterPro | Pfam3D Structure * PDB | PDBe | DrugPort
* ModBase | SwissModel
Structure-based FamilyFamily 7 (CATH: 3.40.50.1000)Historical Class5'(3')-deoxyribonucleotidase
Localization cytoplasm; mitochondrion (PubMed: 12124385, 10899995 | Europe PMC)
Catalytic SiteCatalytic Site Atlas Target by Small MoleculesN/A
Gene ExpressionGene Expression Atlas

The Human Protein Atlas

Function and DiseaseOMIM
Protein-protein Interaction Database STRING | IntAct | MINT
Kinase Database Phospho.ELM | PhosphoSite | NetworKIN
Function (UniProt annotation)
FUNCTION: Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP.
Catalytic Activity (UniProt annotation)
N/A
Protein Sequence
MIRLGGWCAR RLCSAAVPAG RRGAAGGLGL AGGRALRVLV DMDGVLADFE GGFLRKFRAR FPDQPFIALE DRRGFWVSEQ YGRLRPGLSE KAISIWESKN FFFELEPLPG AVEAVKEMAS LQNTDVFICT SPIKMFKYCP YEKYAWVEKY FGPDFLEQIV LTRDKTVVSA DLLIDDRPDI TGAEPTPSWE HVLFTACHNQ HLQLQPPRRR LHSWADDWKA ILDSKRPC
ELM motif
N/A
Gene Ontology
GO:00082535'-nucleotidase activity
GO:0006260DNA replication
GO:0046872metal ion binding
GO:0005759mitochondrial matrix
GO:0000166nucleotide binding
GO:0006206pyrimidine base metabolic process
GO:0046135pyrimidine nucleoside catabolic process

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