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Collapse Statistics
226 human active and 11 inactive phosphatases in total;
194 phosphatases have substrate data;
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305 protein substrates;
89 non-protein substrates;
1114 dephosphorylation interactions;
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213 KEGG pathways;
206 NCI Nature PID pathways
560 Reactome pathways;
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last update: 18 Feb, 2016

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NT5C3

Gene Name NT5C3 (QuickGO)
Structure of phosphatase catalytic domain

PDB ID: 2VKQ
(LeftMouse - Rotate; Shift+Left - Scale; Ctrl+Left - Translate)
SynonymsNT5C3 P5N1 UMPH1 HSPC233
Protein NameCytosolic 5'-nucleotidase 3
Alternative Name(s)
Cytosolic 5'-nucleotidase 3 (EC 3.1.3.5) (Cytosolic 5'-nucleotidase III) (cN-III) (Pyrimidine 5'-nucleotidase 1) (P5'N-1) (P5N-1) (PN-I) (Uridine 5'-monophosphate hydrolase 1) (p36)
Ensembl Gene IDENSG00000122643
EntrezGene ID51251
UniProt AC (Human)Q9H0P0 (protein sequence)
Enzyme ClassEC 3.1.3.5 (BRENDA )
Molecular Weight37948
Protein Length336
Phosphatase activityactive
Protein DomainInterPro | Pfam3D Structure * PDB | PDBe | DrugPort
* ModBase | SwissModel
Structure-based FamilyFamily 7 (CATH: 3.40.50.1000)Historical ClassPyrimidine 5'-nucleotidase family
Localization cytoplasm; endoplasmic reticulum (PubMed: 8557639 | Europe PMC)
Catalytic SiteCatalytic Site Atlas Target by Small MoleculesN/A
Gene ExpressionGene Expression Atlas

The Human Protein Atlas

Function and DiseaseOMIM
Protein-protein Interaction Database STRING | IntAct | MINT
Kinase Database Phospho.ELM | PhosphoSite | NetworKIN
Function (UniProt annotation)
FUNCTION: Can act both as nucleotidase and as phosphotransferase.
Catalytic Activity (UniProt annotation)
CATALYTIC ACTIVITY: A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate.
Protein Sequence
MRAPSMDRAA VARVGAVASA SVCALVAGVV LAQYIFTLKR KTGRKTKIIE MMPEFQKSSV RIKNPTRVEE IICGLIKGGA AKLQIITDFD MTLSRFSYKG KRCPTCHNII DNCKLVTDEC RKKLLQLKEK YYAIEVDPVL TVEEKYPYMV EWYTKSHGLL VQQALPKAKL KEIVAESDVM LKEGYENFFD KLQQHSIPVF IFSAGIGDVL EEVIRQAGVY HPNVKVVSNF MDFDETGVLK GFKGELIHVF NKHDGALRNT EYFNQLKDNS NIILLGDSQG DLRMADGVAN VEHILKIGYL NDRVDELLEK YMDSYDIVLV QDESLEVANS ILQKIL
ELM motif
N/A
Gene Ontology
GO:00086652'-phosphotransferase activity
GO:00082535'-nucleotidase activity
GO:0005829cytosol
GO:0005783endoplasmic reticulum
GO:0000287magnesium ion binding
GO:0000166nucleotide binding
GO:0009117nucleotide metabolic process
GO:0006206pyrimidine base metabolic process
GO:0046135pyrimidine nucleoside catabolic process

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