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Collapse Statistics
226 human active and 11 inactive phosphatases in total;
194 phosphatases have substrate data;
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305 protein substrates;
89 non-protein substrates;
1114 dephosphorylation interactions;
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213 KEGG pathways;
206 NCI Nature PID pathways
560 Reactome pathways;
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last update: 18 Feb, 2016

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NT5C1A

Gene Name NT5C1A (QuickGO)SynonymsNT5C1A
Protein NameCytosolic 5'-nucleotidase 1A
Alternative name(s)
Cytosolic 5'-nucleotidase 1A (cN1A) (EC 3.1.3.5) (Cytosolic 5'-nucleotidase IA) (cN-I) (cN-IA)
Ensembl Gene IDENSG00000116981EntrezGene ID84618
UniProt AC (Human)Q9BXI3 (protein sequence)Enzyme ClassEC 3.1.3.5 (BRENDA )
Molecular Weight41021Protein Length368
Phosphatase activityactive
Protein DomainInterPro | Pfam3D Structure * PDB | PDBe | DrugPort
* ModBase | SwissModel
Structure-based FamilyFamily 14 (CATH: N/A)Historical Class5'-nucleotidase type 3
Localization cytoplasm; cytosol (PubMed: 11690631, 11133996 | Europe PMC)
Catalytic SiteCatalytic Site Atlas Target by Small MoleculesN/A
Gene ExpressionGene Expression Atlas

The Human Protein Atlas

Function and DiseaseOMIM
Protein-protein Interaction Database STRING | IntAct | MINT
Kinase Database Phospho.ELM | PhosphoSite | NetworKIN
Function (UniProt annotation)
FUNCTION: Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia.
Catalytic Activity (UniProt annotation)
CATALYTIC ACTIVITY: A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate.
Protein Sequence
MEPGQPREPQ EPREPGPGAE TAAAPVWEEA KIFYDNLAPK KKPKSPKPQN AVTIAVSSRA LFRMDEEQQI YTEQGVEEYV RYQLEHENEP FSPGPAFPFV KALEAVNRRL RELYPDSEDV FDIVLMTNNH AQVGVRLINS INHYDLFIER FCMTGGNSPI CYLKAYHTNL YLSADAEKVR EAIDEGIAAA TIFSPSRDVV VSQSQLRVAF DGDAVLFSDE SERIVKAHGL DRFFEHEKAH ENKPLAQGPL KGFLEALGRL QKKFYSKGLR LECPIRTYLV TARSAASSGA RALKTLRSWG LETDEALFLA GAPKGPLLEK IRPHIFFDDQ MFHVAGAQEM GTVAAHVPYG VAQTPRRTAP AKQAPSAQ
ELM motif
N/A
Gene Ontology
GO:00082535'-nucleotidase activity
GO:0005829cytosol
GO:0000287magnesium ion binding
GO:0000166nucleotide binding
GO:0006144purine base metabolic process
GO:0006195purine nucleotide catabolic process
GO:0006206pyrimidine base metabolic process
GO:0046135pyrimidine nucleoside catabolic process

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