Statistics
226 human active and 11 inactive phosphatases in total;
194 phosphatases have substrate data;
--------------------------------
305 protein substrates;
89 non-protein substrates;
1114 dephosphorylation interactions;
--------------------------------
213 KEGG pathways;
206 NCI Nature PID pathways
560 Reactome pathways;
--------------------------------
last update: 18 Feb, 2016
194 phosphatases have substrate data;
--------------------------------
305 protein substrates;
89 non-protein substrates;
1114 dephosphorylation interactions;
--------------------------------
213 KEGG pathways;
206 NCI Nature PID pathways
560 Reactome pathways;
--------------------------------
last update: 18 Feb, 2016
NT5C
Gene Name  | NT5C (QuickGO) | PDB ID: 2I7D (LeftMouse - Rotate; Shift+Left - Scale; Ctrl+Left - Translate) |
| Synonyms | NT5C DNT1 UMPH2 | |
| Protein Name | 5'(3')-deoxyribonucleotidase, cytosolic type | |
| Alternative Name(s) | 5'(3')-deoxyribonucleotidase, cytosolic type (EC 3.1.3.-) (Cytosolic 5',3'-pyrimidine nucleotidase) (Deoxy-5'-nucleotidase 1) (dNT-1) | |
| Ensembl Gene ID | ENSG00000125458 | |
| EntrezGene ID | 30833 | |
| UniProt AC (Human) | Q8TCD5 (protein sequence) | |
| Enzyme Class | EC 3.1.3.- (BRENDA ) | |
| Molecular Weight | 23383 | |
| Protein Length | 201 | |
| Phosphatase activity | active |
| Protein Domain | InterPro | Pfam | 3D Structure | * PDB | PDBe | DrugPort * ModBase | SwissModel |
| Structure-based Family | Family 7 (CATH: 3.40.50.1000) | Historical Class | 5'(3')-deoxyribonucleotidase |
| Localization | cytoplasm; cytosol; nucleus (PubMed: 10681516, 2157703 | Europe PMC) | ||
| Catalytic Site | Catalytic Site Atlas | Target by Small Molecules | N/A |
| Gene Expression | Gene Expression Atlas | Function and Disease | OMIM |
| Protein-protein Interaction Database | STRING | IntAct | MINT | ||
| Kinase Database | Phospho.ELM | PhosphoSite | NetworKIN | ||
| Function (UniProt annotation) | |||
| FUNCTION: Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP. | |||
| Catalytic Activity (UniProt annotation) | |||
| N/A | |||
| Protein Sequence | |||
| MARSVRVLVD MDGVLADFEA GLLRGFRRRF PEEPHVPLEQ RRGFLAREQY RALRPDLADK VASVYEAPGF FLDLEPIPGA LDAVREMNDL PDTQVFICTS PLLKYHHCVG EKYRWVEQHL GPQFVERIIL TRDKTVVLGD LLIDDKDTVR GQEETPSWEH ILFTCCHNRH LVLPPTRRRL LSWSDNWREI LDSKRGAAQR E | |||
| ELM motif | |
| N/A |
| Gene Ontology | |
| GO:0008253 | 5'-nucleotidase activity |
| GO:0005829 | cytosol |
| GO:0046872 | metal ion binding |
| GO:0005634 | nucleus |
| GO:0006144 | purine base metabolic process |
| GO:0006195 | purine nucleotide catabolic process |
| GO:0006206 | pyrimidine base metabolic process |
| GO:0009223 | pyrimidine deoxyribonucleotide catabolic process |
| GO:0046135 | pyrimidine nucleoside catabolic process |
| GO:0019103 | pyrimidine nucleotide binding |
