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Collapse Statistics
226 human active and 11 inactive phosphatases in total;
194 phosphatases have substrate data;
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305 protein substrates;
89 non-protein substrates;
1114 dephosphorylation interactions;
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213 KEGG pathways;
206 NCI Nature PID pathways
560 Reactome pathways;
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last update: 18 Feb, 2016

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NT5C

Gene Name NT5C (QuickGO)
Structure of phosphatase catalytic domain

PDB ID: 2I7D
(LeftMouse - Rotate; Shift+Left - Scale; Ctrl+Left - Translate)
SynonymsNT5C DNT1 UMPH2
Protein Name5'(3')-deoxyribonucleotidase, cytosolic type
Alternative Name(s)
5'(3')-deoxyribonucleotidase, cytosolic type (EC 3.1.3.-) (Cytosolic 5',3'-pyrimidine nucleotidase) (Deoxy-5'-nucleotidase 1) (dNT-1)
Ensembl Gene IDENSG00000125458
EntrezGene ID30833
UniProt AC (Human)Q8TCD5 (protein sequence)
Enzyme ClassEC 3.1.3.- (BRENDA )
Molecular Weight23383
Protein Length201
Phosphatase activityactive
Protein DomainInterPro | Pfam3D Structure * PDB | PDBe | DrugPort
* ModBase | SwissModel
Structure-based FamilyFamily 7 (CATH: 3.40.50.1000)Historical Class5'(3')-deoxyribonucleotidase
Localization cytoplasm; cytosol; nucleus (PubMed: 10681516, 2157703 | Europe PMC)
Catalytic SiteCatalytic Site Atlas Target by Small MoleculesN/A
Gene ExpressionGene Expression Atlas

The Human Protein Atlas

Function and DiseaseOMIM
Protein-protein Interaction Database STRING | IntAct | MINT
Kinase Database Phospho.ELM | PhosphoSite | NetworKIN
Function (UniProt annotation)
FUNCTION: Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP.
Catalytic Activity (UniProt annotation)
N/A
Protein Sequence
MARSVRVLVD MDGVLADFEA GLLRGFRRRF PEEPHVPLEQ RRGFLAREQY RALRPDLADK VASVYEAPGF FLDLEPIPGA LDAVREMNDL PDTQVFICTS PLLKYHHCVG EKYRWVEQHL GPQFVERIIL TRDKTVVLGD LLIDDKDTVR GQEETPSWEH ILFTCCHNRH LVLPPTRRRL LSWSDNWREI LDSKRGAAQR E
ELM motif
N/A
Gene Ontology
GO:00082535'-nucleotidase activity
GO:0005829cytosol
GO:0046872metal ion binding
GO:0005634nucleus
GO:0006144purine base metabolic process
GO:0006195purine nucleotide catabolic process
GO:0006206pyrimidine base metabolic process
GO:0009223pyrimidine deoxyribonucleotide catabolic process
GO:0046135pyrimidine nucleoside catabolic process
GO:0019103pyrimidine nucleotide binding

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