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Collapse Statistics
226 human active and 11 inactive phosphatases in total;
194 phosphatases have substrate data;
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305 protein substrates;
89 non-protein substrates;
1114 dephosphorylation interactions;
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213 KEGG pathways;
206 NCI Nature PID pathways
560 Reactome pathways;
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last update: 18 Feb, 2016

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MINPP1

Gene Name MINPP1 (QuickGO)SynonymsMINPP1 MIPP UNQ900/PRO1917
Protein NameMultiple inositol polyphosphate phosphatase 1
Alternative name(s)
Multiple inositol polyphosphate phosphatase 1 (EC 3.1.3.62) (Inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase) (Ins(1,3,4,5)P(4) 3-phosphatase)
Ensembl Gene IDENSG00000107789EntrezGene ID9562
UniProt AC (Human)Q9UNW1 (protein sequence)Enzyme ClassEC 3.1.3.62 (BRENDA )
Molecular Weight55051Protein Length487
Phosphatase activityactive
Protein DomainInterPro | Pfam3D Structure * PDB | PDBe | DrugPort
* ModBase | SwissModel
Structure-based FamilyFamily 8 (CATH: 3.40.50.1240)Historical ClassMultiple inositol-polyphosphate phosphatase
Localization cytoplasm; endoplasmic reticulum (PubMed: 10938126, 9472008 | Europe PMC)
Catalytic SiteCatalytic Site Atlas Target by Small MoleculesN/A
Gene ExpressionGene Expression Atlas

The Human Protein Atlas

Function and DiseaseOMIM
Protein-protein Interaction Database STRING | IntAct | MINT
Kinase Database Phospho.ELM | PhosphoSite | NetworKIN
Function (UniProt annotation)
FUNCTION: Acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6) (By similarity). May play a role in bone development (endochondral ossification).
Catalytic Activity (UniProt annotation)
CATALYTIC ACTIVITY: Myo-inositol hexakisphosphate + H(2)O = myo-inositol pentakisphosphate (mixed isomers) + phosphate.
Protein Sequence
MLRAPGCLLR TSVAPAAALA AALLSSLARC SLLEPRDPVA SSLSPYFGTK TRYEDVNPVL LSGPEAPWRD PELLEGTCTP VQLVALIRHG TRYPTVKQIR KLRQLHGLLQ ARGSRDGGAS STGSRDLGAA LADWPLWYAD WMDGQLVEKG RQDMRQLALR LASLFPALFS RENYGRLRLI TSSKHRCMDS SAAFLQGLWQ HYHPGLPPPD VADMEFGPPT VNDKLMRFFD HCEKFLTEVE KNATALYHVE AFKTGPEMQN ILKKVAATLQ VPVNDLNADL IQVAFFTCSF DLAIKGVKSP WCDVFDIDDA KVLEYLNDLK QYWKRGYGYT INSRSSCTLF QDIFQHLDKA VEQKQRSQPI SSPVILQFGH AETLLPLLSL MGYFKDKEPL TAYNYKKQMH RKFRSGLIVP YASNLIFVLY HCENAKTPKE QFRVQMLLNE KVLPLAYSQE TVSFYEDLKN HYKDILQSCQ TSEECELARA NSTSDEL
ELM motif
N/A
Gene Ontology
GO:0003993acid phosphatase activity
GO:0034417bisphosphoglycerate 3-phosphatase activity
GO:0030282bone mineralization
GO:0005788endoplasmic reticulum lumen
GO:0004446inositol-hexakisphosphate phosphatase activity
GO:0008969phosphohistidine phosphatase activity
GO:0006797polyphosphate metabolic process

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