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Collapse Statistics
226 human active and 11 inactive phosphatases in total;
194 phosphatases have substrate data;
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305 protein substrates;
89 non-protein substrates;
1114 dephosphorylation interactions;
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213 KEGG pathways;
206 NCI Nature PID pathways
560 Reactome pathways;
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last update: 18 Feb, 2016

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INPP1

Gene Name INPP1 (QuickGO)SynonymsINPP1
Protein NameInositol polyphosphate 1-phosphatase
Alternative name(s)
Inositol polyphosphate 1-phosphatase (IPP) (IPPase) (EC 3.1.3.57)
Ensembl Gene IDENSG00000151689EntrezGene ID3628
UniProt AC (Human)P49441 (protein sequence)Enzyme ClassEC 3.1.3.57 (BRENDA )
Molecular Weight43998Protein Length399
Phosphatase activityactive
Protein DomainInterPro | Pfam3D Structure * PDB | PDBe | DrugPort
* ModBase | SwissModel
Structure-based FamilyFamily 10 (CATH: 3.30.540.10, 3.40.190.80)Historical ClassInositol monophosphatase
Localization cytoplasm (PubMed: 8390685 | Europe PMC)
Catalytic SiteCatalytic Site Atlas Target by Small MoleculesN/A
Gene ExpressionGene Expression Atlas

The Human Protein Atlas

Function and DiseaseOMIM
Protein-protein Interaction Database STRING | IntAct | MINT
Kinase Database Phospho.ELM | PhosphoSite | NetworKIN
Function (UniProt annotation)
N/A
Catalytic Activity (UniProt annotation)
CATALYTIC ACTIVITY: 1D-myo-inositol 1,4-bisphosphate + H(2)O = 1D-myo-inositol 4-phosphate + phosphate.
Protein Sequence
MSDILRELLC VSEKAANIAR ACRQQEALFQ LLIEEKKEGE KNKKFAVDFK TLADVLVQEV IKQNMENKFP GLEKNIFGEE SNEFTNDWGE KITLRLCSTE EETAELLSKV LNGNKVASEA LARVVHQDVA FTDPTLDSTE INVPQDILGI WVDPIDSTYQ YIKGSADIKS NQGIFPCGLQ CVTILIGVYD IQTGVPLMGV INQPFVSRDP NTLRWKGQCY WGLSYMGTNM HSLQLTISRR NGSETHTGNT GSEAAFSPSF SAVISTSEKE TIKAALSRVC GDRIFGAAGA GYKSLCVVQG LVDIYIFSED TTFKWDSCAA HAILRAMGGG IVDLKECLER NPETGLDLPQ LVYHVENEGA AGVDRWANKG GLIAYRSRKR LETFLSLLVQ NLAPAETHT
ELM motif
N/A
Gene Ontology
GO:0004441inositol-1,4-bisphosphate 1-phosphatase activity
GO:0046872metal ion binding
GO:0007165signal transduction

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