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Collapse Statistics
226 human active and 11 inactive phosphatases in total;
194 phosphatases have substrate data;
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305 protein substrates;
89 non-protein substrates;
1114 dephosphorylation interactions;
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213 KEGG pathways;
206 NCI Nature PID pathways
560 Reactome pathways;
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last update: 18 Feb, 2016

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IMPA1

Gene Name IMPA1 (QuickGO)
Structure of phosphatase catalytic domain

PDB ID: 1IMB
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SynonymsIMPA1 IMPA
Protein NameInositol monophosphatase 1
Alternative Name(s)
Inositol monophosphatase 1 (IMP 1) (IMPase 1) (EC 3.1.3.25) (Inositol-1(or 4)-monophosphatase 1) (Lithium-sensitive myo-inositol monophosphatase A1)
Ensembl Gene IDENSG00000133731
EntrezGene ID3612
UniProt AC (Human)P29218 (protein sequence)
Enzyme ClassEC 3.1.3.25 (BRENDA )
Molecular Weight30189
Protein Length277
Phosphatase activityactive
Protein DomainInterPro | Pfam3D Structure * PDB | PDBe | DrugPort
* ModBase | SwissModel
Structure-based FamilyFamily 10 (CATH: 3.30.540.10, 3.40.190.80)Historical ClassInositol monophosphatase
Localization cytoplasm (PubMed: 11959401 | Europe PMC)
Catalytic SiteCatalytic Site Atlas Target by Small MoleculesChEMBL
Gene ExpressionGene Expression Atlas

The Human Protein Atlas

Function and DiseaseOMIM
Protein-protein Interaction Database STRING | IntAct | MINT
Kinase Database Phospho.ELM | PhosphoSite | NetworKIN
Function (UniProt annotation)
FUNCTION: Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Can use myo-inositol monophosphates, myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates.
Catalytic Activity (UniProt annotation)
CATALYTIC ACTIVITY: Myo-inositol phosphate + H(2)O = myo-inositol + phosphate.
Protein Sequence
MADPWQECMD YAVTLARQAG EVVCEAIKNE MNVMLKSSPV DLVTATDQKV EKMLISSIKE KYPSHSFIGE ESVAAGEKSI LTDNPTWIID PIDGTTNFVH RFPFVAVSIG FAVNKKIEFG VVYSCVEGKM YTARKGKGAF CNGQKLQVSQ QEDITKSLLV TELGSSRTPE TVRMVLSNME KLFCIPVHGI RSVGTAAVNM CLVATGGADA YYEMGIHCWD VAGAGIIVTE AGGVLMDVTG GPFDLMSRRV IAANNRILAE RIAKEIQVIP LQRDDED
ELM motif
N/A
Gene Ontology
GO:0005737cytoplasm
GO:0008934inositol monophosphate phosphatase activity
GO:0046855inositol phosphate dephosphorylation
GO:0046872metal ion binding
GO:0006661phosphatidylinositol biosynthetic process
GO:0042803protein homodimerization activity
GO:0007165signal transduction

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