Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
Top
FIG4
Gene Name  | FIG4 (QuickGO) | (A quick tutorial to explore the interctive visulaization) |
| Synonyms | FIG4, KIAA0274, SAC3 | |
| Protein Name | FIG4 |
|
| Alternative Name(s) |
Polyphosphoinositide phosphatase;3.1.3.-;Phosphatidylinositol 3,5-bisphosphate 5-phosphatase;SAC domain-containing protein 3; | |
| EntrezGene ID | 9896 (Comparitive Toxicogenomics) | |
| UniProt AC (Human) | Q92562 (protein sequence) | |
| Enzyme Class | N/A | |
| Molecular Weight | 103635 Dalton | |
| Protein Length | 907 amino acids (AA) | |
| Genome Browsers | NCBI | ENSG00000112367 (Ensembl) | UCSC | |
| Crosslinking annotations | Query our ID-mapping table | |
| Orthologues | Quest For Orthologues (QFO) | GeneTree | |
| Classification | Superfamily: SAC domain phosphatases | Historic class: SAC domain family | CATH ID: NA | SCOP Fold: CC1 | |
| Phosphatase activity | active | Catalytic signature motif: NCVDCLDR | |
| Domain organization, Expression, Diseases | (show / hide) |
| Protein Domain | InterPro | Pfam | SMART | 3D Structure | PDB | DrugPort | ModBase | SwissModel |
| Polypeptide organization (Pfam) | No Pfam domain found | ||
| Catalytic Site | Mechanism and Catalytic Site Atlas | ||
| Gene Expression | Gene Expression Atlas | Diseases | OMIM | ClinVar |
| Protein-protein interactions | STRING | IntAct | MINT | BioGRID | ||
| Phosphosites | Phospho.ELM | PhosphoSitePlus | ||
| Localization, Function, Catalytic activity and Sequence | (show / hide) |
| Localization (UniProt annotation) | |||
| Endosome membrane Note=Localization requires VAC14and PIKFYVE | |||
| Function (UniProt annotation) | |||
| The PI(3,5)P2 regulatory complex regulates both thesynthesis and turnover of phosphatidylinositol 3,5-bisphosphate(PtdIns(3,5)P2) In vitro, hydrolyzes all three D5-phosphorylatedpolyphosphoinositide substrates in the order PtdIns(4,5)P2 >PtdIns(3,5)P2 > PtdIns(3,4,5)P3 Plays a role in the biogenesis ofendosome carrier vesicles (ECV) / multivesicular bodies (MVB)transport intermediates from early endosomes | |||
| Catalytic Activity (UniProt annotation) | |||
| NA | |||
| Protein Sequence | |||
| MPTAAAPIISSVQKLVLYETRARYFLVGSNNAETKYRVLKIDRTEPKDLVIIDDRHVYTQQEVRELLGRLDLGNRTKMGQ KGSSGLFRAVSAFGVVGFVRFLEGYYIVLITKRRKMADIGGHAIYKVEDTNMIYIPNDSVRVTHPDEARYLRIFQNVDLS SNFYFSYSYDLSHSLQYNLTVLRMPLEMLKSEMTQNRQESFDIFEDEGLITQGGSGVFGICSEPYMKYVWNGELLDIIKS TVHRDWLLYIIHGFCGQSKLLIYGRPVYVTLIARRSSKFAGTRFLKRGANCEGDVANEVETEQILCDASVMSFTAGSYSS YVQVRGSVPLYWSQDISTMMPKPPITLDQADPFAHVAALHFDQMFQRFGSPIIILNLVKEREKRKHERILSEELVAAVTY LNQFLPPEHTIVYIPWDMAKYTKSKLCNVLDRLNVIAESVVKKTGFFVNRPDSYCSILRPDEKWNELGGCVIPTGRLQTG ILRTNCVDCLDRTNTAQFMVGKCALAYQLYSLGLIDKPNLQFDTDAVRLFEELYEDHGDTLSLQYGGSQLVHRVKTYRKI APWTQHSKDIMQTLSRYYSNAFSDADRQDSINLFLGVFHPTEGKPHLWELPTDFYLHHKNTMRLLPTRRSYTYWWTPEVI KHLPLPYDEVICAVNLKKLIVKKFHKYEEEIDIHNEFFRPYELSSFDDTFCLAMTSSARDFMPKTVGIDPSPFTVRKPDE TGKSVLGNKSNREEAVLQRKTAASAPPPPSEEAVSSSSEDDSGTDREEEGSVSQRSTPVKMTDAGDSAKVTENVVQPMKE LYGINLSDGLSEEDFSIYSRFVQLGQSQHKQDKNSQQPCSRCSDGVIKLTPISAFSQDNIYEVQPPRVDRKSTEIFQAHI QASQGIMQPLGKEDSSMYREYIRNRYL |
| Motif information from Eukaryotic Linear Motif atlas (ELM) | (show / hide) |
ELM Motif | Motif Instance | Description | Motif Regex |
| NA | NA | NA | NA |
| Gene Ontology (P: Process; F: Function and C: Component terms) | (show / hide) | |
| GO:0000139 | C:Golgi membrane |
| GO:0004438 | F:phosphatidylinositol-3-phosphatase activity |
| GO:0005783 | C:endoplasmic reticulum |
| GO:0005811 | C:lipid droplet |
| GO:0006661 | P:phosphatidylinositol biosynthetic process |
| GO:0007033 | P:vacuole organization |
| GO:0007626 | P:locomotory behavior |
| GO:0010008 | C:endosome membrane |
| GO:0010976 | P:positive regulation of neuron projection development |
| GO:0031642 | P:negative regulation of myelination |
| GO:0031901 | C:early endosome membrane |
| GO:0031902 | C:late endosome membrane |
| GO:0032288 | P:myelin assembly |
| GO:0043231 | C:intracellular membrane-bounded organelle |
| GO:0043473 | P:pigmentation |
| GO:0043812 | F:phosphatidylinositol-4-phosphate phosphatase activity |
| GO:0043813 | F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity |
| GO:0048666 | P:neuron development |
| GO:0055037 | C:recycling endosome |
