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Collapse Statistics
226 human active and 11 inactive phosphatases in total;
194 phosphatases have substrate data;
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305 protein substrates;
89 non-protein substrates;
1114 dephosphorylation interactions;
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213 KEGG pathways;
206 NCI Nature PID pathways
560 Reactome pathways;
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last update: 18 Feb, 2016

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FBP2

Gene Name FBP2 (QuickGO)
Structure of phosphatase catalytic domain

PDB ID: 3IFC
(LeftMouse - Rotate; Shift+Left - Scale; Ctrl+Left - Translate)
SynonymsFBP2
Protein NameFructose-1,6-bisphosphatase isozyme 2
Alternative Name(s)
Fructose-1,6-bisphosphatase isozyme 2 (FBPase 2) (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase 2)
Ensembl Gene IDENSG00000130957
EntrezGene ID8789
UniProt AC (Human)O00757 (protein sequence)
Enzyme ClassEC 3.1.3.11 (BRENDA )
Molecular Weight36743
Protein Length339
Phosphatase activityactive
Protein DomainInterPro | Pfam3D Structure * PDB | PDBe | DrugPort
* ModBase | SwissModel
Structure-based FamilyFamily 10 (CATH: 3.30.540.10, 3.40.190.80)Historical ClassFBPase class 1
Localization cytosol (PubMed: 9678974 | Europe PMC)
Catalytic SiteCatalytic Site Atlas Target by Small MoleculesChEMBL
Gene ExpressionGene Expression Atlas

The Human Protein Atlas

Function and DiseaseOMIM
Protein-protein Interaction Database STRING | IntAct | MINT
Kinase Database Phospho.ELM | PhosphoSite | NetworKIN
Function (UniProt annotation)
N/A
Catalytic Activity (UniProt annotation)
CATALYTIC ACTIVITY: D-fructose 1,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate.
Protein Sequence
MTDRSPFETD MLTLTRYVME KGRQAKGTGE LTQLLNSMLT AIKAISSAVR KAGLAHLYGI AGSVNVTGDE VKKLDVLSNS LVINMVQSSY STCVLVSEEN KDAIITAKEK RGKYVVCFDP LDGSSNIDCL ASIGTIFAIY RKTSEDEPSE KDALQCGRNI VAAGYALYGS ATLVALSTGQ GVDLFMLDPA LGEFVLVEKD VKIKKKGKIY SLNEGYAKYF DAATTEYVQK KKFPEDGSAP YGARYVGSMV ADVHRTLVYG GIFLYPANQK SPKGKLRLLY ECNPVAYIIE QAGGLATTGT QPVLDVKPEA IHQRVPLILG SPEDVQEYLT CVQKNQAGS
ELM motif
N/A
Gene Ontology
GO:0005829cytosol
GO:0042132fructose 1,6-bisphosphate 1-phosphatase activity
GO:0006000fructose metabolic process
GO:0004331fructose-2,6-bisphosphate 2-phosphatase activity
GO:0006094gluconeogenesis
GO:0046872metal ion binding

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