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Collapse Statistics
226 human active and 11 inactive phosphatases in total;
194 phosphatases have substrate data;
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305 protein substrates;
89 non-protein substrates;
1114 dephosphorylation interactions;
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213 KEGG pathways;
206 NCI Nature PID pathways
560 Reactome pathways;
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last update: 18 Feb, 2016

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FBP1

Gene Name FBP1 (QuickGO)
Structure of phosphatase catalytic domain

PDB ID: 2JJK
(LeftMouse - Rotate; Shift+Left - Scale; Ctrl+Left - Translate)
SynonymsFBP1 FBP
Protein NameFructose-1,6-bisphosphatase 1
Alternative Name(s)
Fructose-1,6-bisphosphatase 1 (FBPase 1) (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase 1)
Ensembl Gene IDENSG00000165140
EntrezGene ID2203
UniProt AC (Human)P09467 (protein sequence)
Enzyme ClassEC 3.1.3.11 (BRENDA )
Molecular Weight36842
Protein Length338
Phosphatase activityactive
Protein DomainInterPro | Pfam3D Structure * PDB | PDBe | DrugPort
* ModBase | SwissModel
Structure-based FamilyFamily 10 (CATH: 3.30.540.10, 3.40.190.80)Historical ClassFBPase class 1
Localization cytoplasm; cytosol (PubMed: 9380240, 9382095 | Europe PMC)
Catalytic SiteCatalytic Site Atlas Target by Small MoleculesChEMBL
Gene ExpressionGene Expression Atlas

The Human Protein Atlas

Function and DiseaseOMIM
Protein-protein Interaction Database STRING | IntAct | MINT
Kinase Database Phospho.ELM | PhosphoSite | NetworKIN
Function (UniProt annotation)
N/A
Catalytic Activity (UniProt annotation)
CATALYTIC ACTIVITY: D-fructose 1,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate.
Protein Sequence
MADQAPFDTD VNTLTRFVME EGRKARGTGE LTQLLNSLCT AVKAISSAVR KAGIAHLYGI AGSTNVTGDQ VKKLDVLSND LVMNMLKSSF ATCVLVSEED KHAIIVEPEK RGKYVVCFDP LDGSSNIDCL VSVGTIFGIY RKKSTDEPSE KDALQPGRNL VAAGYALYGS ATMLVLAMDC GVNCFMLDPA IGEFILVDKD VKIKKKGKIY SLNEGYARDF DPAVTEYIQR KKFPPDNSAP YGARYVGSMV ADVHRTLVYG GIFLYPANKK SPNGKLRLLY ECNPMAYVME KAGGMATTGK EAVLDVIPTD IHQRAPVILG SPDDVLEFLK VYEKHSAQ
ELM motif
N/A
Gene Ontology
GO:0005829cytosol
GO:0042132fructose 1,6-bisphosphate 1-phosphatase activity
GO:0004331fructose-2,6-bisphosphate 2-phosphatase activity
GO:0006094gluconeogenesis
GO:0042802identical protein binding
GO:0046872metal ion binding

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