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Collapse Statistics
226 human active and 11 inactive phosphatases in total;
194 phosphatases have substrate data;
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305 protein substrates;
89 non-protein substrates;
1114 dephosphorylation interactions;
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213 KEGG pathways;
206 NCI Nature PID pathways
560 Reactome pathways;
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last update: 18 Feb, 2016

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EPM2A

Gene Name EPM2A (QuickGO)SynonymsEPM2A
Protein NameLaforin
Alternative name(s)
Laforin (EC 3.1.3.16) (EC 3.1.3.48) (Lafora PTPase) (LAFPTPase)
Ensembl Gene IDENSG00000112425EntrezGene ID7957
UniProt AC (Human)O95278 (protein sequence)Enzyme ClassEC 3.1.3.16, 3.1.3.48 (BRENDA )
Molecular Weight37158Protein Length331
Phosphatase activityactive
Protein DomainInterPro | Pfam3D Structure * PDB | PDBe | DrugPort
* ModBase | SwissModel
Structure-based FamilyFamily 1 (CATH: 3.90.190.10)Historical ClassPTPs >> Class I Cys-based PTPs >> VH1-like or dual-specificity phosphatases (DSPs) >> Atypical DSPs
Localization cytoplasm; endoplasmic reticulum; nucleus; plasma membrane (PubMed: 11001928, 11220751, 11883934, 11739371, 17908927, 10521265, 2675384 | Europe PMC)
Catalytic SiteCatalytic Site Atlas Target by Small MoleculesN/A
Gene ExpressionGene Expression Atlas

The Human Protein Atlas

Function and DiseaseOMIM
Protein-protein Interaction Database STRING | IntAct | MINT
Kinase Database Phospho.ELM | PhosphoSite | NetworKIN
Function (UniProt annotation)
FUNCTION: Dual specificity protein phosphatase. May be involved in the control of glycogen metabolism, particularly in monitoring for and preventing the formation of poorly branched glycogen molecules (polyglucosans). Acts as a scaffold protein to facilitate PPP1R3C/PTG ubiquitination by NHLRC1/malin. Forms a complex with NHLRC1/malin and HSP70 and this complex suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS).
Catalytic Activity (UniProt annotation)
CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.; CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein + phosphate.
Protein Sequence
MRFRFGVVVP PAVAGARPEL LVVGSRPELG RWEPRGAVRL RPAGTAAGDG ALALQEPGLW LGEVELAAEE AAQDGAEPGR VDTFWYKFLK REPGGELSWE GNGPHHDRCC TYNENNLVDG VYCLPIGHWI EATGHTNEMK HTTDFYFNIA GHQAMHYSRI LPNIWLGSCP RQVEHVTIKL KHELGITAVM NFQTEWDIVQ NSSGCNRYPE PMTPDTMIKL YREEGLAYIW MPTPDMSTEG RVQMLPQAVC LLHALLEKGH IVYVHCNAGV GRSTAAVCGW LQYVMGWNLR KVQYFLMAKR PAVYIDEEAL ARAQEDFFQK FGKVRSSVCS L
ELM motif
N/A
Gene Ontology
GO:0030246carbohydrate binding
GO:0005829cytosol
GO:0005783endoplasmic reticulum
GO:0005977glycogen metabolic process
GO:0042802identical protein binding
GO:0005634nucleus
GO:0005886plasma membrane
GO:0005844polysome
GO:0004722protein serine/threonine phosphatase activity
GO:0004725protein tyrosine phosphatase activity
GO:0008138protein tyrosine/serine/threonine phosphatase activity

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