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Collapse Statistics
226 human active and 11 inactive phosphatases in total;
194 phosphatases have substrate data;
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305 protein substrates;
89 non-protein substrates;
1114 dephosphorylation interactions;
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213 KEGG pathways;
206 NCI Nature PID pathways
560 Reactome pathways;
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last update: 18 Feb, 2016

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DUSP11

Gene Name DUSP11 (QuickGO)SynonymsDUSP11 PIR1
Protein NameRNA/RNP complex-1-interacting phosphatase
Alternative name(s)
RNA/RNP complex-1-interacting phosphatase (EC 3.1.3.-) (Dual specificity protein phosphatase 11) (Phosphatase that interacts with RNA/RNP complex 1)
Ensembl Gene IDENSG00000144048EntrezGene ID8446
UniProt AC (Human)O75319 (protein sequence)Enzyme ClassEC 3.1.3.- (BRENDA )
Molecular Weight38939Protein Length330
Phosphatase activityactive
Protein DomainInterPro | Pfam3D Structure * PDB | PDBe | DrugPort
* ModBase | SwissModel
Structure-based FamilyFamily 1 (CATH: 3.90.190.10)Historical ClassPTPs >> Class I Cys-based PTPs >> VH1-like or dual-specificity phosphatases (DSPs) >> Atypical DSPs
Localization cytoskeleton; nucleus (PubMed: 16381850, 9685386, 15635413, 16381990 | Europe PMC)
Catalytic SiteCatalytic Site Atlas Target by Small MoleculesN/A
Gene ExpressionGene Expression Atlas

The Human Protein Atlas

Function and DiseaseOMIM
Protein-protein Interaction Database STRING | IntAct | MINT
Kinase Database Phospho.ELM | PhosphoSite | NetworKIN
Function (UniProt annotation)
FUNCTION: Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. Binds to RNA. May participate in nuclear mRNA metabolism.
Catalytic Activity (UniProt annotation)
N/A
Protein Sequence
MSQWHHPRSG WGRRRDFSGR SSAKKKGGNH IPERWKDYLP VGQRMPGTRF IAFKVPLQKS FEKKLAPEEC FSPLDLFNKI REQNEELGLI IDLTYTQRYY KPEDLPETVP YLKIFTVGHQ VPDDETIFKF KHAVNGFLKE NKDNDKLIGV HCTHGLNRTG YLICRYLIDV EGVRPDDAIE LFNRCRGHCL ERQNYIEDLQ NGPIRKNWNS SVPRSSDFED SAHLMQPVHN KPVKQGPRYN LHQIQGHSAP RHFHTQTQSL QQSVRKFSEN PHVYQRHHLP PPGPPGEDYS HRRYSWNVKP NASRAAQDRR RWYPYNYSRL SYPACWEWTQ
ELM motif
N/A
Gene Ontology
GO:0003723RNA binding
GO:0006396RNA processing
GO:0005634nucleus
GO:0004725protein tyrosine phosphatase activity
GO:0008138protein tyrosine/serine/threonine phosphatase activity

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