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Collapse Statistics
226 human active and 11 inactive phosphatases in total;
194 phosphatases have substrate data;
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305 protein substrates;
89 non-protein substrates;
1114 dephosphorylation interactions;
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213 KEGG pathways;
206 NCI Nature PID pathways
560 Reactome pathways;
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last update: 18 Feb, 2016

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BPNT1

Gene Name BPNT1 (QuickGO)
Structure of phosphatase catalytic domain

PDB ID: 2WEF
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SynonymsBPNT1
Protein Name3'(2'),5'-bisphosphate nucleotidase 1
Alternative Name(s)
3'(2'),5'-bisphosphate nucleotidase 1 (EC 3.1.3.7) (Bisphosphate 3'-nucleotidase 1) (PAP-inositol-1,4-phosphatase) (PIP)
Ensembl Gene IDENSG00000162813
EntrezGene ID10380
UniProt AC (Human)O95861 (protein sequence)
Enzyme ClassEC 3.1.3.7 (BRENDA )
Molecular Weight33392
Protein Length308
Phosphatase activityactive
Protein DomainInterPro | Pfam3D Structure * PDB | PDBe | DrugPort
* ModBase | SwissModel
Structure-based FamilyFamily 10 (CATH: 3.30.540.10, 3.40.190.80)Historical ClassInositol monophosphatase
Localization cytosol (PubMed: 10224133 | Europe PMC)
Catalytic SiteCatalytic Site Atlas Target by Small MoleculesN/A
Gene ExpressionGene Expression Atlas

The Human Protein Atlas

Function and DiseaseOMIM
Protein-protein Interaction Database STRING | IntAct | MINT
Kinase Database Phospho.ELM | PhosphoSite | NetworKIN
Function (UniProt annotation)
FUNCTION: Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Has 1000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2) and inositol 1,3,4-trisphosphate (Ins(1,3,4)P3), but does not hydrolyze Ins(1)P, Ins(3,4)P2, Ins(1,3,4,5)P4 or InsP6.
Catalytic Activity (UniProt annotation)
CATALYTIC ACTIVITY: Adenosine 3',5'-bisphosphate + H(2)O = adenosine 5'-phosphate + phosphate.
Protein Sequence
MASSNTVLMR LVASAYSIAQ KAGMIVRRVI AEGDLGIVEK TCATDLQTKA DRLAQMSICS SLARKFPKLT IIGEEDLPSE EVDQELIEDS QWEEILKQPC PSQYSAIKEE DLVVWVDPLD GTKEYTEGLL DNVTVLIGIA YEGKAIAGVI NQPYYNYEAG PDAVLGRTIW GVLGLGAFGF QLKEVPAGKH IITTTRSHSN KLVTDCVAAM NPDAVLRVGG AGNKIIQLIE GKASAYVFAS PGCKKWDTCA PEVILHAVGG KLTDIHGNVL QYHKDVKHMN SAGVLATLRN YDYYASRVPE SIKNALVP
ELM motif
N/A
Gene Ontology
GO:00084413'(2'),5'-bisphosphate nucleotidase activity
GO:00504273'-phosphoadenosine 5'-phosphosulfate metabolic process
GO:0005829cytosol
GO:0007399nervous system development
GO:0006805xenobiotic metabolic process

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