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Collapse Statistics
226 human active and 11 inactive phosphatases in total;
194 phosphatases have substrate data;
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305 protein substrates;
89 non-protein substrates;
1114 dephosphorylation interactions;
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213 KEGG pathways;
206 NCI Nature PID pathways
560 Reactome pathways;
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last update: 18 Feb, 2016

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ALPI

Gene Name ALPI (QuickGO)SynonymsALPI
Protein NameIntestinal-type alkaline phosphatase
Alternative name(s)
Intestinal-type alkaline phosphatase (IAP) (Intestinal alkaline phosphatase) (EC 3.1.3.1)
Ensembl Gene IDENSG00000163295EntrezGene ID248
UniProt AC (Human)P09923 (protein sequence)Enzyme ClassEC 3.1.3.1 (BRENDA )
Molecular Weight56812Protein Length528
Phosphatase activityactive
Protein DomainInterPro | Pfam3D Structure * PDB | PDBe | DrugPort
* ModBase | SwissModel
Structure-based FamilyFamily 9 (CATH: 3.40.720.10)Historical ClassAlkaline phosphatase
Localization cytoplasm; extracellular region; nucleus; plasma membrane (PubMed: 12466148, 12577238, 12660142 | Europe PMC)
Catalytic SiteCatalytic Site Atlas Target by Small MoleculesChEMBL
Gene ExpressionGene Expression Atlas

The Human Protein Atlas

Function and DiseaseOMIM
Protein-protein Interaction Database STRING | IntAct | MINT
Kinase Database Phospho.ELM | PhosphoSite | NetworKIN
Function (UniProt annotation)
N/A
Catalytic Activity (UniProt annotation)
CATALYTIC ACTIVITY: A phosphate monoester + H(2)O = an alcohol + phosphate.
Protein Sequence
MQGPWVLLLL GLRLQLSLGV IPAEEENPAF WNRQAAEALD AAKKLQPIQK VAKNLILFLG DGLGVPTVTA TRILKGQKNG KLGPETPLAM DRFPYLALSK TYNVDRQVPD SAATATAYLC GVKANFQTIG LSAAARFNQC NTTRGNEVIS VMNRAKQAGK SVGVVTTTRV QHASPAGTYA HTVNRNWYSD ADMPASARQE GCQDIATQLI SNMDIDVILG GGRKYMFPMG TPDPEYPADA SQNGIRLDGK NLVQEWLAKH QGAWYVWNRT ELMQASLDQS VTHLMGLFEP GDTKYEIHRD PTLDPSLMEM TEAALRLLSR NPRGFYLFVE GGRIDHGHHE GVAYQALTEA VMFDDAIERA GQLTSEEDTL TLVTADHSHV FSFGGYTLRG SSIFGLAPSK AQDSKAYTSI LYGNGPGYVF NSGVRPDVNE SESGSPDYQQ QAAVPLSSET HGGEDVAVFA RGPQAHLVHG VQEQSFVAHV MAFAACLEPY TACDLAPPAC TTDAAHPVAA SLPLLAGTLL LLGASAAP
ELM motif
N/A
Gene Ontology
GO:0004035alkaline phosphatase activity
GO:0031225anchored to membrane
GO:0016021integral to membrane
GO:0046872metal ion binding
GO:0016310phosphorylation
GO:0005886plasma membrane
GO:0005515protein binding

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