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Collapse Statistics
226 human active and 11 inactive phosphatases in total;
194 phosphatases have substrate data;
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305 protein substrates;
89 non-protein substrates;
1114 dephosphorylation interactions;
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213 KEGG pathways;
206 NCI Nature PID pathways
560 Reactome pathways;
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last update: 18 Feb, 2016

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ACPP

Gene Name ACPP (QuickGO)
Structure of phosphatase catalytic domain

PDB ID: 1ND5
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SynonymsACPP
Protein NameProstatic acid phosphatase
Alternative Name(s)
Prostatic acid phosphatase (EC 3.1.3.2)
Ensembl Gene IDENSG00000014257
EntrezGene ID55
UniProt AC (Human)P15309 (protein sequence)
Enzyme ClassEC 3.1.3.2, 3.1.3.5 (BRENDA )
Molecular Weight44566
Protein Length386
Phosphatase activityactive
Protein DomainInterPro | Pfam3D Structure * PDB | PDBe | DrugPort
* ModBase | SwissModel
Structure-based FamilyFamily 8 (CATH: 3.40.50.1240)Historical ClassHistidine acid phosphatase
Localization cytoplasm; extracellular region; lysosome; nucleus; secreted; vacuole (PubMed: 12525165, 11547122, 9187691, 10477906, 12433721, 2411954, 7923807, 17897319 | Europe PMC)
Catalytic SiteCatalytic Site Atlas Target by Small MoleculesChEMBL
Gene ExpressionGene Expression Atlas

The Human Protein Atlas

Function and DiseaseOMIM
Protein-protein Interaction Database STRING | IntAct | MINT
Kinase Database Phospho.ELM | PhosphoSite | NetworKIN
Function (UniProt annotation)
FUNCTION: A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma.; FUNCTION: Isoform 2: the cellular form also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor. Acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling.
Catalytic Activity (UniProt annotation)
CATALYTIC ACTIVITY: A phosphate monoester + H(2)O = an alcohol + phosphate.; CATALYTIC ACTIVITY: A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate.
Protein Sequence
MRAAPLLLAR AASLSLGFLF LLFFWLDRSV LAKELKFVTL VFRHGDRSPI DTFPTDPIKE SSWPQGFGQL TQLGMEQHYE LGEYIRKRYR KFLNESYKHE QVYIRSTDVD RTLMSAMTNL AALFPPEGVS IWNPILLWQP IPVHTVPLSE DQLLYLPFRN CPRFQELESE TLKSEEFQKR LHPYKDFIAT LGKLSGLHGQ DLFGIWSKVY DPLYCESVHN FTLPSWATED TMTKLRELSE LSLLSLYGIH KQKEKSRLQG GVLVNEILNH MKRATQIPSY KKLIMYSAHD TTVSGLQMAL DVYNGLLPPY ASCHLTELYF EKGEYFVEMY YRNETQHEPY PLMLPGCSPS CPLERFAELV GPVIPQDWST ECMTTNSHQG TEDSTD
ELM motif
N/A
Gene Ontology
GO:00082535'-nucleotidase activity
GO:0003993acid phosphatase activity
GO:0005576extracellular region
GO:0005765lysosomal membrane

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