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Collapse Statistics
226 human active and 11 inactive phosphatases in total;
194 phosphatases have substrate data;
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305 protein substrates;
89 non-protein substrates;
1114 dephosphorylation interactions;
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213 KEGG pathways;
206 NCI Nature PID pathways
560 Reactome pathways;
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last update: 18 Feb, 2016

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ACP1

Gene Name ACP1 (QuickGO)
Structure of phosphatase catalytic domain

PDB ID: 5PNT
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SynonymsACP1
Protein NameLow molecular weight phosphotyrosine protein phosphatase
Alternative Name(s)
Low molecular weight phosphotyrosine protein phosphatase (LMW-PTP) (LMW-PTPase) (EC 3.1.3.48) (Adipocyte acid phosphatase) (Low molecular weight cytosolic acid phosphatase) (EC 3.1.3.2) (Red cell acid phosphatase 1)
Ensembl Gene IDENSG00000143727
EntrezGene ID52
UniProt AC (Human)P24666 (protein sequence)
Enzyme ClassEC 3.1.3.2, 3.1.3.48 (BRENDA )
Molecular Weight18042
Protein Length158
Phosphatase activityactive
Protein DomainInterPro | Pfam3D Structure * PDB | PDBe | DrugPort
* ModBase | SwissModel
Structure-based FamilyFamily 2 (CATH: 3.40.50.270)Historical ClassPTPs >> Class II Cys-based PTPs (LMPTP)
Localization cytoplasm (PubMed: 1587862 | Europe PMC)
Catalytic SiteCatalytic Site Atlas Target by Small MoleculesChEMBL
Gene ExpressionGene Expression Atlas

The Human Protein Atlas

Function and DiseaseOMIM
Protein-protein Interaction Database STRING | IntAct | MINT
Kinase Database Phospho.ELM | PhosphoSite | NetworKIN
Function (UniProt annotation)
FUNCTION: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity.
Catalytic Activity (UniProt annotation)
CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.; CATALYTIC ACTIVITY: A phosphate monoester + H(2)O = an alcohol + phosphate.
Protein Sequence
MAEQATKSVL FVCLGNICRS PIAEAVFRKL VTDQNISENW RVDSAATSGY EIGNPPDYRG QSCMKRHGIP MSHVARQITK EDFATFDYIL CMDESNLRDL NRKSNQVKTC KAKIELLGSY DPQKQLIIED PYYGNDSDFE TVYQQCVRCC RAFLEKAH
ELM motif
N/A
Gene Ontology
GO:0003993acid phosphatase activity
GO:0005737cytoplasm
GO:0042802identical protein binding
GO:0009898internal side of plasma membrane
GO:0004726non-membrane spanning protein tyrosine phosphatase activity
GO:0005634nucleus
GO:0005625soluble fraction

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