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Collapse Statistics
226 human active and 11 inactive phosphatases in total;
194 phosphatases have substrate data;
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305 protein substrates;
89 non-protein substrates;
1114 dephosphorylation interactions;
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213 KEGG pathways;
206 NCI Nature PID pathways
560 Reactome pathways;
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last update: 18 Feb, 2016

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MDP1

Gene Name MDP1 (QuickGO)
Structure of phosphatase catalytic domain

PDB ID: 2WM8
(LeftMouse - Rotate; Shift+Left - Scale; Ctrl+Left - Translate)
SynonymsMDP1
Protein NameMagnesium-dependent phosphatase 1
Alternative Name(s)
Magnesium-dependent phosphatase 1 (MDP-1) (EC 3.1.3.-) (EC 3.1.3.48)
Ensembl Gene IDENSG00000213920
EntrezGene ID145553
UniProt AC (Human)Q86V88 (protein sequence)
Enzyme ClassEC 3.1.3.-, 3.1.3.48 (BRENDA )
Molecular Weight20109
Protein Length176
Phosphatase activityactive
Protein DomainInterPro | Pfam3D Structure * PDB | PDBe | DrugPort
* ModBase | SwissModel
Structure-based FamilyFamily 7 (CATH: 3.40.50.1000)Historical ClassHAD-like hydrolase
Localization N/A
Catalytic SiteCatalytic Site Atlas Target by Small MoleculesN/A
Gene ExpressionGene Expression Atlas

The Human Protein Atlas

Function and DiseaseOMIM
Protein-protein Interaction Database STRING | IntAct | MINT
Kinase Database Phospho.ELM | PhosphoSite | NetworKIN
Function (UniProt annotation)
FUNCTION: Magnesium-dependent phosphatase which may act as a tyrosine phosphatase (By similarity).
Catalytic Activity (UniProt annotation)
CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
Protein Sequence
MARLPKLAVF DLDYTLWPFW VDTHVDPPFH KSSDGTVRDR RGQDVRLYPE VPEVLKRLQS LGVPGAAASR TSEIEGANQL LELFDLFRYF VHREIYPGSK ITHFERLQQK TGIPFSQMIF FDDERRNIVD VSKLGVTCIH IQNGMNLQTL SQGLETFAKA QTGPLRSSLE ESPFEA
ELM motif
N/A
Gene Ontology
GO:0046872metal ion binding
GO:0004725protein tyrosine phosphatase activity

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